======= STT3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STT3A
  * **<color #00a2e8>Official Name</color>**: STT3 oligosaccharyltransferase complex catalytic subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3703|3703]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46977|P46977]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STT3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STT3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601134|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post- translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. {ECO:0000250|UniProtKB:F1PJP5, ECO:0000269|PubMed:19167329, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STT3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oligosaccharyltransferase III complex|
|co-translational protein modification|
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-3.04|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.84|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.54|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.48|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.4|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.31|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.28|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.26|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.21|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.2|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.1|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.07|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.06|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.03|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.96|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.9|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.89|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.85|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.83|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.83|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.83|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.79|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.78|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.75|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.72|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.7|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.73|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.75|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.85|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.86|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.92|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.01|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.09|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.14|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.8|
|[[:results:exp539|42°C R08 exp539]]|3.12|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec62|SEC62]]|0.487|
|[[:human genes:u:ube2g2|UBE2G2]]|0.476|
|[[:human genes:d:dnajb11|DNAJB11]]|0.475|
|[[:human genes:p:pmm2|PMM2]]|0.462|
|[[:human genes:t:tmed10|TMED10]]|0.451|
|[[:human genes:a:alg5|ALG5]]|0.442|
|[[:human genes:t:triap1|TRIAP1]]|0.434|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.431|
|[[:human genes:r:rptor|RPTOR]]|0.431|
|[[:human genes:h:hars|HARS]]|0.427|
|[[:human genes:c:chchd4|CHCHD4]]|0.427|
|[[:human genes:s:sec63|SEC63]]|0.423|
|[[:human genes:d:dpagt1|DPAGT1]]|0.421|
|[[:human genes:t:trmt5|TRMT5]]|0.421|
|[[:human genes:u:uba5|UBA5]]|0.421|
|[[:human genes:u:ube2j1|UBE2J1]]|0.419|
|[[:human genes:c:cbfb|CBFB]]|0.418|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.418|
|[[:human genes:a:alg6|ALG6]]|0.414|
|[[:human genes:d:dad1|DAD1]]|0.414|
|[[:human genes:c:cbx3|CBX3]]|0.408|
|[[:human genes:u:uap1|UAP1]]|0.408|
|[[:human genes:g:gmppb|GMPPB]]|0.405|
|[[:human genes:z:zfx|ZFX]]|0.405|
|[[:human genes:d:dpm1|DPM1]]|0.404|
|[[:human genes:m:manf|MANF]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STT3A Expression in NALM6 Cells: 8.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>