======= STX12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX12
  * **<color #00a2e8>Official Name</color>**: syntaxin 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23673|23673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86Y82|Q86Y82]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:G3V7P1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|Syntaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic recycling endosome|
|BLOC-1 complex|
|cholesterol efflux|
|phagophore assembly site|
|SNAP receptor activity|
|integral component of synaptic vesicle membrane|
|SNARE complex|
|cholesterol transport|
|phagocytic vesicle|
|autophagosome assembly|
|vesicle docking|
|SNARE binding|
|autophagosome organization|
|sterol transport|
|vesicle fusion|
|endomembrane system|
|organelle membrane fusion|
|recycling endosome membrane|
|organelle fusion|
|synaptic vesicle|
|vacuole organization|
|membrane fusion|
|organic hydroxy compound transport|
|vesicle|
|early endosome membrane|
|macroautophagy|
|organelle localization by membrane tethering|
|protein stabilization|
|membrane docking|
|membrane raft|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of protein stability|
|lipid transport|
|vesicle organization|
|lipid localization|
|organelle localization|
|Golgi membrane|
|organelle assembly|
|membrane organization|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.72|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.83|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.88|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.9|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15219
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX12 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>