======= STX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX3
  * **<color #00a2e8>Official Name</color>**: syntaxin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6809|6809]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13277|Q13277]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600876|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potentially involved in docking of synaptic vesicles at presynaptic active zones.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syntaxin|
|SNARE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|
|arachidonic acid binding|
|presynaptic active zone membrane|
|synaptic vesicle docking|
|azurophil granule|
|zymogen granule membrane|
|specific granule|
|synaptic vesicle fusion to presynaptic active zone membrane|
|vesicle fusion to plasma membrane|
|vacuole|
|neurotransmitter receptor transport to plasma membrane|
|positive regulation of protein localization to cell surface|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|SNAP receptor activity|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|regulation of protein localization to cell surface|
|receptor localization to synapse|
|vesicle docking involved in exocytosis|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|long-term synaptic potentiation|
|SNARE complex|
|positive regulation of protein localization to plasma membrane|
|positive regulation of protein localization to cell periphery|
|protein localization to synapse|
|vesicle docking|
|synaptic vesicle exocytosis|
|SNARE binding|
|exocytic process|
|vesicle fusion|
|presynaptic membrane|
|endomembrane system|
|organelle membrane fusion|
|Schaffer collateral - CA1 synapse|
|postsynapse|
|vesicle-mediated transport to the plasma membrane|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|melanosome|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of protein localization to cell periphery|
|synaptic vesicle cycle|
|synaptic vesicle|
|positive regulation of protein localization to membrane|
|growth cone|
|vesicle-mediated transport in synapse|
|membrane fusion|
|positive regulation of chemotaxis|
|positive regulation of synaptic transmission|
|signal release|
|organelle localization by membrane tethering|
|cell-cell junction|
|neurotransmitter transport|
|lamellipodium|
|membrane docking|
|regulation of protein localization to membrane|
|regulation of synaptic plasticity|
|regulation of chemotaxis|
|protein localization to cell periphery|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|vesicle organization|
|apical plasma membrane|
|neuron projection|
|positive regulation of cellular protein localization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of cell adhesion|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|organelle localization|
|positive regulation of response to external stimulus|
|neuron projection development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulated exocytosis|
|exocytosis|
|neuron development|
|membrane organization|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|regulation of locomotion|
|intracellular protein transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|export from cell|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16931
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX3 Expression in NALM6 Cells: 4.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>