======= STYX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STYX
  * **<color #00a2e8>Official Name</color>**: serine/threonine/tyrosine interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6815|6815]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUJ0|Q8WUJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STYX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STYX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615814|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:23847209}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process|
|regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|pseudophosphatase activity|
|F-box domain binding|
|MAPK export from nucleus|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|protein tyrosine/serine/threonine phosphatase activity|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of cellular protein catabolic process|
|negative regulation of protein binding|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|protein export from nucleus|
|regulation of ubiquitin-dependent protein catabolic process|
|nuclear export|
|negative regulation of binding|
|regulation of proteasomal protein catabolic process|
|protein dephosphorylation|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of ERK1 and ERK2 cascade|
|dephosphorylation|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of proteolysis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.7|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.42|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.28|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.16|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.14|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.1|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.93|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.87|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STYX Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>