======= SUCLA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUCLA2
  * **<color #00a2e8>Official Name</color>**: succinate-CoA ligase ADP-forming subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8803|8803]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2R7|Q9P2R7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUCLA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUCLA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603921|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-grasp 2|
|Ligase CoA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|succinyl-CoA pathway|
|uroporphyrinogen III metabolic process|
|uroporphyrinogen III biosynthetic process|
|succinate-CoA ligase complex|
|succinate-CoA ligase (ADP-forming) activity|
|succinyl-CoA metabolic process|
|succinate metabolic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|tricarboxylic acid cycle|
|porphyrin-containing compound metabolic process|
|tetrapyrrole metabolic process|
|aerobic respiration|
|acyl-CoA metabolic process|
|dicarboxylic acid metabolic process|
|thioester metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|cellular respiration|
|cofactor biosynthetic process|
|magnesium ion binding|
|energy derivation by oxidation of organic compounds|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.9|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.77|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.45|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.4|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.29|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.29|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.26|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.88|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.82|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.73|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.91|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.2|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.23|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.87|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|6.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:suclg1|SUCLG1]]|0.627|
|[[:human genes:g:glrx5|GLRX5]]|0.575|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.521|
|[[:human genes:h:hmbs|HMBS]]|0.466|
|[[:human genes:i:isca2|ISCA2]]|0.463|
|[[:human genes:i:iba57|IBA57]]|0.459|
|[[:human genes:h:hars|HARS]]|0.459|
|[[:human genes:n:nfu1|NFU1]]|0.458|
|[[:human genes:t:tpk1|TPK1]]|0.415|
|[[:human genes:a:abhd11|ABHD11]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUCLA2 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>