======= SULT1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULT1B1
  * **<color #00a2e8>Official Name</color>**: sulfotransferase family 1B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27284|27284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43704|O43704]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULT1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULT1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608436|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. {ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aryl sulfotransferase activity|
|ethanol catabolic process|
|flavonoid metabolic process|
|primary alcohol catabolic process|
|sulfation|
|thyroid hormone metabolic process|
|ethanol metabolic process|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|purine ribonucleoside bisphosphate metabolic process|
|sulfotransferase activity|
|antibiotic catabolic process|
|alcohol catabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|phenol-containing compound metabolic process|
|antibiotic metabolic process|
|xenobiotic metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|drug catabolic process|
|cellular response to xenobiotic stimulus|
|cellular modified amino acid metabolic process|
|hormone metabolic process|
|steroid metabolic process|
|response to xenobiotic stimulus|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|regulation of hormone levels|
|nucleobase-containing small molecule metabolic process|
|epithelial cell differentiation|
|organophosphate metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|epithelium development|
|lipid metabolic process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULT1B1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>