======= SUMO1 =======
== Gene Information ==
* **Official Symbol**: SUMO1
* **Official Name**: small ubiquitin like modifier 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7341|7341]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P63165|P63165]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=SUMO1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUMO1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/601912|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.
|Rad60-SLD|
|ubiquitin|
|SUMO activating enzyme complex|
|protein localization to nuclear pore|
|nuclear stress granule|
|positive regulation of ATPase-coupled calcium transmembrane transporter activity|
|small protein activating enzyme binding|
|PML body organization|
|negative regulation of action potential|
|protein localization to nuclear envelope|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|protein tag|
|negative regulation of delayed rectifier potassium channel activity|
|negative regulation of voltage-gated potassium channel activity|
|XY body|
|transcription corepressor binding|
|nuclear body organization|
|glucocorticoid receptor binding|
|regulation of delayed rectifier potassium channel activity|
|negative regulation of potassium ion transmembrane transporter activity|
|ubiquitin-like protein ligase binding|
|negative regulation of potassium ion transmembrane transport|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|heterochromatin|
|negative regulation of potassium ion transport|
|regulation of cardiac muscle cell contraction|
|cellular response to cadmium ion|
|positive regulation of calcium ion transmembrane transporter activity|
|potassium channel regulator activity|
|regulation of actin filament-based movement|
|negative regulation of cation channel activity|
|regulation of action potential|
|negative regulation of DNA binding|
|regulation of potassium ion transmembrane transporter activity|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|response to cadmium ion|
|protein sumoylation|
|positive regulation of calcium ion transmembrane transport|
|cellular response to heat|
|negative regulation of ion transmembrane transporter activity|
|nuclear pore|
|regulation of cardiac muscle contraction|
|protein binding, bridging|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|regulation of calcium ion transmembrane transporter activity|
|roof of mouth development|
|regulation of striated muscle contraction|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|positive regulation of ubiquitin-dependent protein catabolic process|
|PML body|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of proteasomal protein catabolic process|
|response to heat|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of calcium ion transport|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA binding|
|nucleus organization|
|fibrillar center|
|positive regulation of cellular protein catabolic process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of ion transmembrane transport|
|negative regulation of DNA-binding transcription factor activity|
|regulation of muscle contraction|
|protein localization to nucleus|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of binding|
|regulation of cation channel activity|
|regulation of response to cytokine stimulus|
|response to temperature stimulus|
|protein stabilization|
|nuclear envelope|
|double-strand break repair|
|regulation of proteasomal protein catabolic process|
|protein C-terminus binding|
|cellular response to metal ion|
|positive regulation of transmembrane transport|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|cellular response to inorganic substance|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|positive regulation of protein complex assembly|
|regulation of cellular protein catabolic process|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse|
|positive regulation of ion transport|
|regulation of transporter activity|
|nuclear body|
|regulation of protein stability|
|regulation of blood circulation|
|ubiquitin protein ligase binding|
|peptidyl-lysine modification|
|transcription factor binding|
|regulation of cation transmembrane transport|
|enzyme binding|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to metal ion|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|nuclear speck|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|regulation of innate immune response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|DNA repair|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|response to inorganic substance|
|regulation of transmembrane transport|
|regulation of system process|
|regulation of ion transport|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|DNA metabolic process|
|regulation of defense response|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of cellular component movement|
|regulation of protein localization|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of transport|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.79|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.94|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.08|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.92|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 9861
* **Expression level (log2 read counts)**: 6.43
{{:chemogenomics:nalm6 dist.png?nolink |}}