======= SUN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUN1
  * **<color #00a2e8>Official Name</color>**: Sad1 and UNC84 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23353|23353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94901|O94901]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sad1 UNC|
|MRP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear matrix anchoring at nuclear membrane|
|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|
|nuclear matrix organization|
|modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration|
|meiotic attachment of telomere to nuclear envelope|
|chromosome attachment to the nuclear envelope|
|meiotic telomere tethering at nuclear periphery|
|telomere tethering at nuclear periphery|
|nuclear migration along microtubule|
|cell motility involved in cerebral cortex radial glia guided migration|
|cytoskeletal anchoring at nuclear membrane|
|meiotic nuclear membrane microtubule tethering complex|
|meiotic telomere clustering|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|telomere localization|
|protein membrane anchor|
|integral component of nuclear inner membrane|
|lamin binding|
|maintenance of protein location in nucleus|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|nuclear migration|
|nucleus localization|
|centrosome localization|
|cerebral cortex radially oriented cell migration|
|microtubule organizing center localization|
|glial cell migration|
|maintenance of protein localization in organelle|
|cerebral cortex cell migration|
|synapsis|
|nuclear envelope organization|
|homologous chromosome segregation|
|telencephalon cell migration|
|forebrain cell migration|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|maintenance of protein location in cell|
|organelle transport along microtubule|
|meiotic chromosome segregation|
|maintenance of location in cell|
|maintenance of protein location|
|meiosis I|
|meiosis I cell cycle process|
|cerebral cortex development|
|nucleus organization|
|meiotic nuclear division|
|transport along microtubule|
|protein localization to nucleus|
|maintenance of location|
|meiotic cell cycle process|
|pallium development|
|cytoskeleton-dependent intracellular transport|
|nuclear envelope|
|microtubule-based transport|
|response to mechanical stimulus|
|gliogenesis|
|nuclear chromosome segregation|
|meiotic cell cycle|
|nuclear membrane|
|telencephalon development|
|ossification|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|forebrain development|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|microtubule-based process|
|intracellular membrane-bounded organelle|
|gamete generation|
|protein localization to organelle|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|cell migration|
|central nervous system development|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|response to abiotic stimulus|
|locomotion|
|cell cycle|
|reproductive process|
|reproduction|
|intracellular transport|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUN1 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>