======= SUN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUN2
  * **<color #00a2e8>Official Name</color>**: Sad1 and UNC84 domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25777|25777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UH99|Q9UH99]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin- dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome- nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sad1 UNC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear migration along microfilament|
|nuclear matrix anchoring at nuclear membrane|
|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|
|nuclear matrix organization|
|modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration|
|cell motility involved in cerebral cortex radial glia guided migration|
|nuclear migration along microtubule|
|actin filament-based transport|
|cytoskeletal anchoring at nuclear membrane|
|meiotic nuclear membrane microtubule tethering complex|
|protein membrane anchor|
|lamin binding|
|integral component of nuclear inner membrane|
|cerebral cortex radial glia guided migration|
|maintenance of protein location in nucleus|
|telencephalon glial cell migration|
|nuclear migration|
|nucleus localization|
|centrosome localization|
|cerebral cortex radially oriented cell migration|
|condensed nuclear chromosome|
|microtubule organizing center localization|
|glial cell migration|
|maintenance of protein localization in organelle|
|cerebral cortex cell migration|
|nuclear envelope organization|
|telencephalon cell migration|
|forebrain cell migration|
|maintenance of protein location in cell|
|mitotic spindle organization|
|organelle transport along microtubule|
|maintenance of location in cell|
|microtubule cytoskeleton organization involved in mitosis|
|maintenance of protein location|
|nuclear chromosome, telomeric region|
|actin filament-based movement|
|cerebral cortex development|
|nucleus organization|
|spindle organization|
|transport along microtubule|
|protein localization to nucleus|
|maintenance of location|
|pallium development|
|cytoskeleton-dependent intracellular transport|
|nuclear envelope|
|microtubule-based transport|
|endosome membrane|
|gliogenesis|
|meiotic cell cycle|
|nuclear membrane|
|microtubule binding|
|telencephalon development|
|microtubule-based movement|
|establishment of organelle localization|
|forebrain development|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|actin filament-based process|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|protein localization to organelle|
|brain development|
|head development|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|identical protein binding|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|locomotion|
|cell cycle|
|reproductive process|
|reproduction|
|intracellular transport|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3683
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUN2 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>