======= SUPT16H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUPT16H
  * **<color #00a2e8>Official Name</color>**: SPT16 homolog, facilitates chromatin remodeling subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11198|11198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5B9|Q9Y5B9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUPT16H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUPT16H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605012|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M24|
|SPT16|
|Rtt106|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FACT complex|
|positive regulation of transcription elongation from RNA polymerase II promoter|
|nucleosome disassembly|
|chromatin disassembly|
|protein-DNA complex disassembly|
|nucleosome binding|
|regulation of transcription elongation from RNA polymerase II promoter|
|positive regulation of DNA-templated transcription, elongation|
|DNA replication-independent nucleosome organization|
|regulation of DNA-templated transcription, elongation|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|chromosome|
|histone binding|
|chromatin assembly or disassembly|
|nucleosome organization|
|regulation of signal transduction by p53 class mediator|
|DNA replication|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|cellular component disassembly|
|transcription by RNA polymerase II|
|DNA repair|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.569|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 443/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|24/28|
|bone|18/25|
|breast|19/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|8/15|
|kidney|21/21|
|liver|9/20|
|lung|33/75|
|lymphocyte|9/14|
|ovary|18/26|
|pancreas|11/24|
|peripheral nervous system|6/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|4/7|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|18/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUPT16H Expression in NALM6 Cells: 9.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>