======= SUV420H1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KMT5B
  * **<color #00a2e8>Official Name</color>**: lysine methyltransferase 5B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51111|51111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4FZB7|Q4FZB7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUV420H1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUV420H1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610881|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269|PubMed:23720823}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone methyltransferase activity (H4-K20 specific)|
|histone H4-K20 trimethylation|
|histone H4-K20 methylation|
|condensed nuclear chromosome, centromeric region|
|histone-lysine N-methyltransferase activity|
|peptidyl-lysine trimethylation|
|histone lysine methylation|
|peptidyl-lysine methylation|
|histone methylation|
|protein alkylation|
|protein methylation|
|macromolecule methylation|
|muscle organ development|
|methylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|muscle structure development|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.94|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.7|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.75|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.78|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.81|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.92|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.92|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.94|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.95|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.97|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.99|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.04|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.07|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.08|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.08|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.11|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.13|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.13|
|[[:results:exp539|42°C R08 exp539]]|2.21|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.22|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.23|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.24|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.41|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.53|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.55|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.58|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.63|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.593|
|[[:human genes:u:ube2g2|UBE2G2]]|0.498|
|[[:human genes:f:faf2|FAF2]]|0.456|
|[[:human genes:c:cycs|CYCS]]|0.449|
|[[:human genes:p:pmm2|PMM2]]|0.435|
|[[:human genes:e:eny2|ENY2]]|0.433|
|[[:human genes:m:mfn1|MFN1]]|0.43|
|[[:human genes:n:nxt1|NXT1]]|0.424|
|[[:human genes:r:rptor|RPTOR]]|0.419|
|[[:human genes:u:ube2k|UBE2K]]|0.418|
|[[:human genes:h:hccs|HCCS]]|0.411|
|[[:human genes:c:crls1|CRLS1]]|0.406|
|[[:human genes:t:taz|TAZ]]|0.402|
|[[:human genes:m:meaf6|MEAF6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUV420H1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>