======= SWAP70 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SWAP70
  * **<color #00a2e8>Official Name</color>**: switching B cell complex subunit SWAP70
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23075|23075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UH65|Q9UH65]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SWAP70&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SWAP70|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604762|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell-cell adhesion mediated by integrin|
|negative regulation of peptidyl-serine dephosphorylation|
|regulation of peptidyl-serine dephosphorylation|
|positive regulation of mast cell chemotaxis|
|regulation of mast cell chemotaxis|
|regulation of cell-cell adhesion mediated by integrin|
|negative regulation of cell adhesion mediated by integrin|
|somatic diversification of immunoglobulins involved in immune response|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|somatic recombination of immunoglobulin gene segments|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|somatic diversification of immunoglobulins|
|negative regulation of actin filament depolymerization|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|B cell activation involved in immune response|
|regulation of cell adhesion mediated by integrin|
|somatic diversification of immune receptors|
|regulation of actin filament depolymerization|
|negative regulation of protein depolymerization|
|positive regulation of actin filament bundle assembly|
|actin filament bundle assembly|
|negative regulation of protein dephosphorylation|
|actin filament bundle organization|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|positive regulation of leukocyte chemotaxis|
|regulation of actin filament bundle assembly|
|lymphocyte activation involved in immune response|
|negative regulation of dephosphorylation|
|regulation of leukocyte chemotaxis|
|regulation of protein complex disassembly|
|positive regulation of leukocyte migration|
|negative regulation of supramolecular fiber organization|
|positive regulation of chemotaxis|
|negative regulation of cytoskeleton organization|
|regulation of protein dephosphorylation|
|B cell activation|
|immunoglobulin production|
|negative regulation of cell-cell adhesion|
|lamellipodium|
|production of molecular mediator of immune response|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|regulation of dephosphorylation|
|regulation of chemotaxis|
|positive regulation of cytoskeleton organization|
|DNA recombination|
|actin filament organization|
|regulation of actin filament organization|
|lymphocyte mediated immunity|
|negative regulation of cell adhesion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of cytosolic calcium ion concentration|
|cadherin binding|
|regulation of cytosolic calcium ion concentration|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of cellular component size|
|lymphocyte activation|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|adaptive immune response|
|positive regulation of organelle organization|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|immune system development|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|DNA metabolic process|
|leukocyte mediated immunity|
|ion homeostasis|
|regulation of cell migration|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|DNA binding|
|ATP binding|
|homeostatic process|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SWAP70 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>