======= SYN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYN1
  * **<color #00a2e8>Official Name</color>**: synapsin I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6853|6853]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17600|P17600]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/313440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RimK|
|Synapsin N|
|Synapsin|
|Synapsin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of synaptic vesicle membrane|
|synaptic vesicle clustering|
|anchored component of synaptic vesicle membrane|
|synaptonemal complex|
|presynaptic active zone|
|transporter activity|
|synaptic vesicle localization|
|calcium-dependent protein binding|
|synaptic vesicle membrane|
|regulation of synaptic vesicle exocytosis|
|Schaffer collateral - CA1 synapse|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|signal release|
|neurotransmitter transport|
|vesicle localization|
|regulation of exocytosis|
|postsynaptic density|
|actin binding|
|synapse organization|
|axon|
|regulation of neurotransmitter levels|
|cytoskeleton|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein kinase binding|
|cell junction|
|regulation of vesicle-mediated transport|
|organelle localization|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|regulation of cellular localization|
|Golgi apparatus|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell-cell signaling|
|secretion|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYN1 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>