======= SYP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYP
  * **<color #00a2e8>Official Name</color>**: synaptophysin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6855|6855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08247|P08247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/313475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MARVEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of opioid receptor signaling pathway|
|synaptic vesicle membrane organization|
|synaptic vesicle maturation|
|regulation of short-term neuronal synaptic plasticity|
|syntaxin-1 binding|
|regulation of long-term neuronal synaptic plasticity|
|excitatory synapse|
|integral component of synaptic vesicle membrane|
|presynaptic active zone|
|SH2 domain binding|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|cholesterol binding|
|terminal bouton|
|synaptic vesicle recycling|
|regulation of neuronal synaptic plasticity|
|protein self-association|
|synaptic vesicle membrane|
|presynaptic membrane|
|neuromuscular junction|
|regulation of synaptic vesicle exocytosis|
|Schaffer collateral - CA1 synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of regulated secretory pathway|
|regulation of synaptic plasticity|
|regulation of exocytosis|
|developmental maturation|
|vesicle organization|
|neuron projection|
|regulation of neurotransmitter levels|
|endomembrane system organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|import into cell|
|perinuclear region of cytoplasm|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|regulation of cellular localization|
|identical protein binding|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.86|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18878
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYP Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>