======= SYT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT7
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9066|9066]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43581|O43581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604146|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)- regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle-mediated cholesterol transport|
|calcium ion regulated lysosome exocytosis|
|short-term synaptic potentiation|
|phagosome-lysosome fusion|
|regulation of glucagon secretion|
|early phagosome|
|plasma membrane repair|
|phagolysosome assembly|
|dense core granule|
|intracellular cholesterol transport|
|intracellular sterol transport|
|positive regulation of calcium ion-dependent exocytosis|
|calcium ion-regulated exocytosis of neurotransmitter|
|exocytic vesicle|
|hippocampal mossy fiber to CA3 synapse|
|intracellular lipid transport|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|phagosome maturation|
|regulation of bone remodeling|
|synaptic vesicle recycling|
|positive regulation of regulated secretory pathway|
|cholesterol transport|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|peroxisomal membrane|
|integral component of presynaptic membrane|
|lysosome organization|
|lytic vacuole organization|
|phosphatidylserine binding|
|regulation of catecholamine secretion|
|synaptic vesicle exocytosis|
|SNARE binding|
|sterol transport|
|synaptic vesicle membrane|
|vesicle fusion|
|regulation of tissue remodeling|
|phagocytic vesicle membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|organelle membrane fusion|
|cellular response to calcium ion|
|positive regulation of exocytosis|
|plasma membrane organization|
|regulation of amine transport|
|regulation of phagocytosis|
|organelle fusion|
|regulation of response to drug|
|neurotransmitter secretion|
|signal release from synapse|
|peroxisome|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|vacuole organization|
|membrane fusion|
|organic hydroxy compound transport|
|cytosolic transport|
|response to calcium ion|
|regulation of regulated secretory pathway|
|signal release|
|regulation of insulin secretion|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|calmodulin binding|
|regulation of peptide hormone secretion|
|cellular response to inorganic substance|
|regulation of exocytosis|
|lysosome|
|regulation of hormone secretion|
|axon|
|lipid transport|
|vesicle organization|
|lysosomal membrane|
|lipid localization|
|neuron projection|
|phagocytosis|
|regulation of neurotransmitter levels|
|response to metal ion|
|positive regulation of secretion by cell|
|endomembrane system organization|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of protein secretion|
|wound healing|
|regulation of peptide secretion|
|regulation of hormone levels|
|response to inorganic substance|
|cell junction|
|regulation of vesicle-mediated transport|
|response to wounding|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|exocytosis|
|regulation of secretion|
|membrane organization|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|intracellular transport|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.83|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.83|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT7 Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>