======= SYT9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT9
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=143425|143425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SS6|Q86SS6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent activation of synaptic vesicle fusion|
|positive regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|positive regulation of synaptic vesicle exocytosis|
|positive regulation of vesicle fusion|
|presynaptic modulation of chemical synaptic transmission|
|dense core granule|
|positive regulation of calcium ion-dependent exocytosis|
|positive regulation of neurotransmitter secretion|
|exocytic vesicle|
|regulation of vesicle fusion|
|hippocampal mossy fiber to CA3 synapse|
|integral component of synaptic vesicle membrane|
|positive regulation of neurotransmitter transport|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|positive regulation of regulated secretory pathway|
|clathrin-coated vesicle membrane|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|phosphatidylserine binding|
|regulation of catecholamine secretion|
|synaptic vesicle exocytosis|
|SNARE binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of synaptic vesicle exocytosis|
|cellular response to calcium ion|
|positive regulation of exocytosis|
|regulation of amine transport|
|secretory granule membrane|
|regulation of response to drug|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|response to calcium ion|
|regulation of regulated secretory pathway|
|signal release|
|regulation of insulin secretion|
|neurotransmitter transport|
|cellular response to metal ion|
|regulation of peptide hormone secretion|
|cellular response to inorganic substance|
|regulation of exocytosis|
|regulation of hormone secretion|
|regulation of neurotransmitter levels|
|response to metal ion|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|response to inorganic substance|
|cell junction|
|regulation of vesicle-mediated transport|
|positive regulation of organelle organization|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|membrane organization|
|regulation of cellular localization|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|identical protein binding|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.79|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.71|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.585|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.583|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.556|
|[[:human genes:t:tfip11|TFIP11]]|0.555|
|[[:human genes:m:mt1e|MT1E]]|0.54|
|[[:human genes:c:cope|COPE]]|0.534|
|[[:human genes:s:slc4a1|SLC4A1]]|0.519|
|[[:human genes:p:psma6|PSMA6]]|0.512|
|[[:human genes:n:nupl1|NUPL1]]|0.512|
|[[:human genes:d:ddtl|DDTL]]|0.508|
|[[:human genes:c:chd4|CHD4]]|0.508|
|[[:human genes:r:rps12|RPS12]]|0.505|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.504|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.502|
|[[:human genes:a:aqr|AQR]]|0.5|
|[[:human genes:s:ssh2|SSH2]]|0.496|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.494|
|[[:human genes:s:supt6h|SUPT6H]]|0.49|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.489|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.489|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.489|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.489|
|[[:human genes:h:hap1|HAP1]]|0.487|
|[[:human genes:c:cdc45|CDC45]]|0.487|
|[[:human genes:p:polr2j3|POLR2J3]]|0.486|
|[[:human genes:v:vasn|VASN]]|0.485|
|[[:human genes:u:ubap1|UBAP1]]|0.483|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.482|
|[[:human genes:d:dtl|DTL]]|0.476|
|[[:human genes:f:fam25b|FAM25B]]|0.475|
|[[:human genes:p:psmb4|PSMB4]]|0.474|
|[[:human genes:r:rrp15|RRP15]]|0.474|
|[[:human genes:r:rplp1|RPLP1]]|0.471|
|[[:human genes:o:orc1|ORC1]]|0.471|
|[[:human genes:c:cmya5|CMYA5]]|0.47|
|[[:human genes:e:exosc5|EXOSC5]]|0.47|
|[[:human genes:r:rad21|RAD21]]|0.466|
|[[:human genes:c:ccna2|CCNA2]]|0.466|
|[[:human genes:c:ctage4|CTAGE4]]|0.464|
|[[:human genes:r:rbm39|RBM39]]|0.459|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.458|
|[[:human genes:p:psmc1|PSMC1]]|0.458|
|[[:human genes:s:sf3a2|SF3A2]]|0.455|
|[[:human genes:r:rfpl3|RFPL3]]|0.454|
|[[:human genes:p:psmc6|PSMC6]]|0.451|
|[[:human genes:c:copg1|COPG1]]|0.451|
|[[:human genes:o:or10g3|OR10G3]]|0.45|
|[[:human genes:r:rpl34|RPL34]]|0.45|
|[[:human genes:g:golga6a|GOLGA6A]]|0.45|
|[[:human genes:c:cbwd3|CBWD3]]|0.45|
|[[:human genes:p:psmd11|PSMD11]]|0.45|
|[[:human genes:s:sec13|SEC13]]|0.449|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.448|
|[[:human genes:c:cactin|CACTIN]]|0.448|
|[[:human genes:r:rrn3|RRN3]]|0.448|
|[[:human genes:c:c14orf93|C14orf93]]|0.447|
|[[:human genes:r:rbbp5|RBBP5]]|0.447|
|[[:human genes:t:tceb3c|TCEB3C]]|0.446|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.446|
|[[:human genes:r:rps14|RPS14]]|0.446|
|[[:human genes:m:myo1h|MYO1H]]|0.444|
|[[:human genes:g:gar1|GAR1]]|0.444|
|[[:human genes:k:krt78|KRT78]]|0.443|
|[[:human genes:p:polr2d|POLR2D]]|0.443|
|[[:human genes:z:zfand5|ZFAND5]]|0.442|
|[[:human genes:o:orc6|ORC6]]|0.442|
|[[:human genes:r:rpl35|RPL35]]|0.441|
|[[:human genes:g:golga8j|GOLGA8J]]|0.441|
|[[:human genes:u:utp3|UTP3]]|0.441|
|[[:human genes:m:myb|MYB]]|0.441|
|[[:human genes:p:plk1|PLK1]]|0.44|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.44|
|[[:human genes:r:rfxank|RFXANK]]|0.44|
|[[:human genes:r:rad51|RAD51]]|0.439|
|[[:human genes:c:ccdc94|CCDC94]]|0.439|
|[[:human genes:a:akirin2|AKIRIN2]]|0.438|
|[[:human genes:s:sel1l|SEL1L]]|0.437|
|[[:human genes:f:fam160a1|FAM160A1]]|0.436|
|[[:human genes:c:cbwd5|CBWD5]]|0.436|
|[[:human genes:s:scaf1|SCAF1]]|0.435|
|[[:human genes:s:snrnp70|SNRNP70]]|0.434|
|[[:human genes:a:ankle1|ANKLE1]]|0.432|
|[[:human genes:s:slc25a36|SLC25A36]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.431|
|[[:human genes:f:fcn2|FCN2]]|0.43|
|[[:human genes:n:napa|NAPA]]|0.43|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.43|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.429|
|[[:human genes:n:nol8|NOL8]]|0.428|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.428|
|[[:human genes:m:med14|MED14]]|0.427|
|[[:human genes:e:exd1|EXD1]]|0.426|
|[[:human genes:c:chmp2a|CHMP2A]]|0.425|
|[[:human genes:m:madcam1|MADCAM1]]|0.424|
|[[:human genes:n:nol10|NOL10]]|0.424|
|[[:human genes:o:ogfr|OGFR]]|0.424|
|[[:human genes:c:cdc73|CDC73]]|0.423|
|[[:human genes:g:golga8h|GOLGA8H]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.423|
|[[:human genes:s:smg7|SMG7]]|0.422|
|[[:human genes:r:rnf4|RNF4]]|0.422|
|[[:human genes:n:nup153|NUP153]]|0.422|
|[[:human genes:p:polr2f|POLR2F]]|0.422|
|[[:human genes:t:tuba8|TUBA8]]|0.42|
|[[:human genes:p:psmd13|PSMD13]]|0.42|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.419|
|[[:human genes:c:col15a1|COL15A1]]|0.419|
|[[:human genes:l:lrr1|LRR1]]|0.418|
|[[:human genes:i:iscu|ISCU]]|0.418|
|[[:human genes:m:med29|MED29]]|0.417|
|[[:human genes:m:myh2|MYH2]]|0.416|
|[[:human genes:c:cdh24|CDH24]]|0.416|
|[[:human genes:p:psmd3|PSMD3]]|0.416|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.415|
|[[:human genes:c:cbwd6|CBWD6]]|0.415|
|[[:human genes:r:rps2|RPS2]]|0.414|
|[[:human genes:r:rps28|RPS28]]|0.414|
|[[:human genes:p:ppan|PPAN]]|0.414|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.414|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.414|
|[[:human genes:n:nbpf10|NBPF10]]|0.413|
|[[:human genes:p:psmb1|PSMB1]]|0.413|
|[[:human genes:s:slc38a7|SLC38A7]]|0.413|
|[[:human genes:s:sult2b1|SULT2B1]]|0.412|
|[[:human genes:z:znf106|ZNF106]]|0.412|
|[[:human genes:x:xab2|XAB2]]|0.411|
|[[:human genes:l:loc643669|LOC643669]]|0.411|
|[[:human genes:s:snrpa1|SNRPA1]]|0.411|
|[[:human genes:i:ik|IK]]|0.41|
|[[:human genes:h:haus4|HAUS4]]|0.41|
|[[:human genes:s:s1pr4|S1PR4]]|0.409|
|[[:human genes:d:ddx47|DDX47]]|0.409|
|[[:human genes:r:rpl6|RPL6]]|0.408|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.408|
|[[:human genes:g:gbf1|GBF1]]|0.408|
|[[:human genes:k:kif11|KIF11]]|0.407|
|[[:human genes:p:psmd1|PSMD1]]|0.407|
|[[:human genes:p:psap|PSAP]]|0.406|
|[[:human genes:p:psmb2|PSMB2]]|0.405|
|[[:human genes:d:dock6|DOCK6]]|0.404|
|[[:human genes:y:ythdc1|YTHDC1]]|0.404|
|[[:human genes:a:aatf|AATF]]|0.404|
|[[:human genes:t:twistnb|TWISTNB]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.403|
|[[:human genes:p:ppfia4|PPFIA4]]|0.403|
|[[:human genes:t:tsg101|TSG101]]|0.403|
|[[:human genes:s:sult1a4|SULT1A4]]|0.402|
|[[:human genes:c:cwc15|CWC15]]|0.402|
|[[:human genes:s:sult1a3|SULT1A3]]|0.402|
|[[:human genes:m:mcoln1|MCOLN1]]|0.402|
|[[:human genes:k:kif3c|KIF3C]]|0.402|
|[[:human genes:a:acsf2|ACSF2]]|0.402|
|[[:human genes:m:med15|MED15]]|0.402|
|[[:human genes:n:narfl|NARFL]]|0.401|
|[[:human genes:n:nbpf16|NBPF16]]|0.401|
|[[:human genes:c:cnpy3|CNPY3]]|0.401|
|[[:human genes:c:cln6|CLN6]]|0.401|
|[[:human genes:c:cnot1|CNOT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2419
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT9 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>