======= TAF1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF1B
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor, RNA polymerase I subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9014|9014]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53T94|Q53T94]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500, ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRN7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I core factor complex|
|RNA polymerase transcription factor SL1 complex|
|nucleolar large rRNA transcription by RNA polymerase I|
|RNA polymerase I CORE element sequence-specific DNA binding|
|RNA polymerase I preinitiation complex assembly|
|rRNA transcription|
|TBP-class protein binding|
|transcription elongation from RNA polymerase I promoter|
|transcription preinitiation complex assembly|
|termination of RNA polymerase I transcription|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.08|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.73|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.442|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 62/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|3/25|
|breast|3/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|4/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|2/14|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF1B Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>