======= TAL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAL1
  * **<color #00a2e8>Official Name</color>**: TAL bHLH transcription factor 1, erythroid differentiation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6886|6886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17542|P17542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lsd1/2 complex|
|hemangioblast cell differentiation|
|basophil differentiation|
|regulation of mast cell differentiation|
|positive regulation of chromatin assembly or disassembly|
|astrocyte fate commitment|
|primitive hemopoiesis|
|regulation of chromatin assembly or disassembly|
|negative regulation of erythrocyte differentiation|
|hematopoietic stem cell differentiation|
|spinal cord association neuron differentiation|
|glial cell fate commitment|
|erythrocyte maturation|
|definitive hemopoiesis|
|megakaryocyte development|
|granulocyte differentiation|
|platelet formation|
|platelet morphogenesis|
|embryonic hemopoiesis|
|megakaryocyte differentiation|
|dorsal spinal cord development|
|bone cell development|
|mesodermal cell differentiation|
|regulation of stem cell population maintenance|
|positive regulation of erythrocyte differentiation|
|erythrocyte development|
|positive regulation of signaling receptor activity|
|histone deacetylase complex|
|regulation of erythrocyte differentiation|
|E-box binding|
|astrocyte differentiation|
|cell differentiation in spinal cord|
|positive regulation of protein tyrosine kinase activity|
|myeloid cell development|
|RNA polymerase II transcription factor binding|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of hematopoietic stem cell differentiation|
|negative regulation of myeloid cell differentiation|
|erythrocyte differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|hematopoietic progenitor cell differentiation|
|positive regulation of cell division|
|regulation of protein tyrosine kinase activity|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|positive regulation of chromatin organization|
|myeloid cell homeostasis|
|spinal cord development|
|formation of primary germ layer|
|histone deacetylase binding|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of stem cell differentiation|
|mesoderm development|
|anatomical structure maturation|
|negative regulation of hemopoiesis|
|positive regulation of mitotic cell cycle|
|stem cell differentiation|
|cell maturation|
|gastrulation|
|regulation of cell division|
|glial cell differentiation|
|regulation of signaling receptor activity|
|positive regulation of chromosome organization|
|central nervous system neuron differentiation|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|locomotory behavior|
|homeostasis of number of cells|
|bone development|
|transcription factor complex|
|gliogenesis|
|transcription regulatory region DNA binding|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|nuclear chromatin|
|developmental maturation|
|cell fate commitment|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte differentiation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|leukocyte differentiation|
|enzyme binding|
|regulation of chromosome organization|
|positive regulation of cell cycle|
|chromatin binding|
|blood vessel morphogenesis|
|embryonic organ development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|positive regulation of kinase activity|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|tube morphogenesis|
|positive regulation of transferase activity|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAL1 Expression in NALM6 Cells: 0.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>