======= TANK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TANK
  * **<color #00a2e8>Official Name</color>**: TRAF family member associated NFKB activator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10010|10010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92844|Q92844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TANK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TANK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ubiquitin-specific protease activity|
|deubiquitinase activator activity|
|regulation of ubiquitin-specific protease activity|
|positive regulation of protein deubiquitination|
|regulation of protein deubiquitination|
|TRIF-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to ionizing radiation|
|I-kappaB kinase/NF-kappaB signaling|
|toll-like receptor signaling pathway|
|thiol-dependent ubiquitin-specific protease activity|
|pattern recognition receptor signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|response to ionizing radiation|
|cellular response to radiation|
|cellular response to interleukin-1|
|positive regulation of peptidase activity|
|response to interleukin-1|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|activation of innate immune response|
|response to tumor necrosis factor|
|ubiquitin protein ligase binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|response to radiation|
|regulation of peptidase activity|
|regulation of innate immune response|
|positive regulation of defense response|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|protein-containing complex|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|viral process|
|regulation of proteolysis|
|regulation of defense response|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TANK Expression in NALM6 Cells: 3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>