======= TAPBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAPBP
  * **<color #00a2e8>Official Name</color>**: TAP binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6892|6892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15533|O15533]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAPBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAPBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601962|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TAP complex binding|
|peptide antigen stabilization|
|MHC class Ib protein complex assembly|
|peptide stabilization|
|ATPase-coupled peptide antigen transmembrane transporter activity|
|TAP2 binding|
|TAP1 binding|
|MHC protein complex assembly|
|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|
|MHC class I peptide loading complex|
|regulation of protein complex stability|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|antigen processing and presentation of endogenous peptide antigen|
|MHC class I protein binding|
|antigen processing and presentation of endogenous antigen|
|integral component of lumenal side of endoplasmic reticulum membrane|
|peptide antigen binding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle fusion|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|organelle membrane fusion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|organelle fusion|
|antigen processing and presentation of peptide antigen via MHC class I|
|membrane fusion|
|unfolded protein binding|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|vesicle organization|
|Golgi vesicle transport|
|peptide metabolic process|
|Golgi membrane|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAPBP Expression in NALM6 Cells: 7.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>