======= TAZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAZ
  * **<color #00a2e8>Official Name</color>**: tafazzin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6901|6901]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16635|Q16635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cardiolipin metabolic process|
|regulation of cardiolipin metabolic process|
|1-acylglycerophosphocholine O-acyltransferase activity|
|cardiolipin acyl-chain remodeling|
|cardiolipin biosynthetic process|
|O-acyltransferase activity|
|phosphatidylglycerol biosynthetic process|
|positive regulation of ATP biosynthetic process|
|cardiolipin metabolic process|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|regulation of ATP biosynthetic process|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|phosphatidylglycerol metabolic process|
|cristae formation|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|inner mitochondrial membrane organization|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of phospholipid metabolic process|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|cardiac muscle contraction|
|regulation of phospholipid metabolic process|
|heart contraction|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|heart process|
|striated muscle contraction|
|respiratory electron transport chain|
|oxidative phosphorylation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|skeletal muscle tissue development|
|mitochondrial membrane organization|
|skeletal muscle organ development|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|cardiac muscle tissue development|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|energy derivation by oxidation of organic compounds|
|phospholipid biosynthetic process|
|muscle contraction|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|blood circulation|
|mitochondrial inner membrane|
|regulation of lipid metabolic process|
|circulatory system process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|mitochondrion organization|
|muscle structure development|
|heart development|
|organophosphate biosynthetic process|
|hemopoiesis|
|lipid biosynthetic process|
|hematopoietic or lymphoid organ development|
|immune system development|
|cellular protein-containing complex assembly|
|membrane organization|
|circulatory system development|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.13|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.95|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.71|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.71|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.8|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.81|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.83|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.86|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.9|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.9|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.91|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.01|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.02|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.06|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.06|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.08|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.08|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.1|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.12|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.12|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.13|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.15|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.19|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.21|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.23|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.23|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.26|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.27|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.28|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.3|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.34|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.39|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.51|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.53|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.55|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.57|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.6|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.6|
|[[:results:exp539|42°C R08 exp539]]|2.66|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.7|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.86|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.04|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.04|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.05|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.24|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.38|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.63|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|3.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|4.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.715|
|[[:human genes:t:triap1|TRIAP1]]|0.676|
|[[:human genes:o:opa1|OPA1]]|0.653|
|[[:human genes:r:romo1|ROMO1]]|0.633|
|[[:human genes:h:hars|HARS]]|0.619|
|[[:human genes:p:pmm2|PMM2]]|0.614|
|[[:human genes:t:tamm41|TAMM41]]|0.592|
|[[:human genes:s:slc25a26|SLC25A26]]|0.562|
|[[:human genes:s:srp14|SRP14]]|0.556|
|[[:human genes:d:dnlz|DNLZ]]|0.554|
|[[:human genes:d:dohh|DOHH]]|0.553|
|[[:human genes:t:thg1l|THG1L]]|0.55|
|[[:human genes:r:rpe|RPE]]|0.538|
|[[:human genes:t:timm13|TIMM13]]|0.534|
|[[:human genes:u:uap1|UAP1]]|0.53|
|[[:human genes:h:hccs|HCCS]]|0.529|
|[[:human genes:a:alg1|ALG1]]|0.521|
|[[:human genes:d:dpagt1|DPAGT1]]|0.52|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.519|
|[[:human genes:a:atp5a1|ATP5A1]]|0.518|
|[[:human genes:a:aars|AARS]]|0.512|
|[[:human genes:h:hspd1|HSPD1]]|0.511|
|[[:human genes:r:rtcb|RTCB]]|0.505|
|[[:human genes:p:pggt1b|PGGT1B]]|0.503|
|[[:human genes:p:ppa2|PPA2]]|0.501|
|[[:human genes:c:chchd4|CHCHD4]]|0.5|
|[[:human genes:r:rnmt|RNMT]]|0.5|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.498|
|[[:human genes:g:gfpt1|GFPT1]]|0.498|
|[[:human genes:a:apaf1|APAF1]]|0.498|
|[[:human genes:c:cbfb|CBFB]]|0.493|
|[[:human genes:t:trmt10a|TRMT10A]]|0.491|
|[[:human genes:a:alg13|ALG13]]|0.49|
|[[:human genes:g:gnb1l|GNB1L]]|0.49|
|[[:human genes:a:alg2|ALG2]]|0.486|
|[[:human genes:r:rptor|RPTOR]]|0.484|
|[[:human genes:g:gmppb|GMPPB]]|0.483|
|[[:human genes:u:ube2g2|UBE2G2]]|0.48|
|[[:human genes:p:ppcs|PPCS]]|0.48|
|[[:human genes:a:alg5|ALG5]]|0.48|
|[[:human genes:p:plaa|PLAA]]|0.48|
|[[:human genes:a:atp5o|ATP5O]]|0.477|
|[[:human genes:t:tmem41b|TMEM41B]]|0.477|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.476|
|[[:human genes:t:trnt1|TRNT1]]|0.476|
|[[:human genes:c:casp9|CASP9]]|0.474|
|[[:human genes:c:cycs|CYCS]]|0.473|
|[[:human genes:u:uhrf1|UHRF1]]|0.472|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.471|
|[[:human genes:c:coq3|COQ3]]|0.47|
|[[:human genes:d:dhps|DHPS]]|0.469|
|[[:human genes:u:ube2j1|UBE2J1]]|0.468|
|[[:human genes:m:mrpl23|MRPL23]]|0.467|
|[[:human genes:p:pdss1|PDSS1]]|0.465|
|[[:human genes:n:nae1|NAE1]]|0.463|
|[[:human genes:a:atp5d|ATP5D]]|0.461|
|[[:human genes:m:mrps14|MRPS14]]|0.461|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.46|
|[[:human genes:e:exoc4|EXOC4]]|0.459|
|[[:human genes:m:mrps18a|MRPS18A]]|0.453|
|[[:human genes:a:atp5b|ATP5B]]|0.452|
|[[:human genes:a:atxn10|ATXN10]]|0.452|
|[[:human genes:p:parl|PARL]]|0.451|
|[[:human genes:b:bak1|BAK1]]|0.45|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.449|
|[[:human genes:c:cct7|CCT7]]|0.447|
|[[:human genes:m:mrpl21|MRPL21]]|0.447|
|[[:human genes:t:timm8b|TIMM8B]]|0.447|
|[[:human genes:t:timm17a|TIMM17A]]|0.446|
|[[:human genes:t:tkt|TKT]]|0.444|
|[[:human genes:t:tufm|TUFM]]|0.444|
|[[:human genes:u:utp23|UTP23]]|0.442|
|[[:human genes:m:mrps5|MRPS5]]|0.441|
|[[:human genes:a:atp5j|ATP5J]]|0.441|
|[[:human genes:h:haus8|HAUS8]]|0.44|
|[[:human genes:a:alg6|ALG6]]|0.44|
|[[:human genes:e:eif3f|EIF3F]]|0.437|
|[[:human genes:r:rab10|RAB10]]|0.437|
|[[:human genes:m:mrps34|MRPS34]]|0.436|
|[[:human genes:o:oraov1|ORAOV1]]|0.435|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.435|
|[[:human genes:m:mtor|MTOR]]|0.435|
|[[:human genes:p:pam16|PAM16]]|0.431|
|[[:human genes:m:mrps11|MRPS11]]|0.431|
|[[:human genes:m:mrps9|MRPS9]]|0.428|
|[[:human genes:r:rpn1|RPN1]]|0.427|
|[[:human genes:l:lsm11|LSM11]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.425|
|[[:human genes:s:slc25a20|SLC25A20]]|0.424|
|[[:human genes:d:dhrsx|DHRSX]]|0.423|
|[[:human genes:t:tbca|TBCA]]|0.421|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.42|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.42|
|[[:human genes:p:pisd|PISD]]|0.42|
|[[:human genes:l:lonp1|LONP1]]|0.418|
|[[:human genes:d:dusp12|DUSP12]]|0.418|
|[[:human genes:t:tprkb|TPRKB]]|0.418|
|[[:human genes:w:wbscr16|WBSCR16]]|0.418|
|[[:human genes:b:bap1|BAP1]]|0.417|
|[[:human genes:s:sec62|SEC62]]|0.417|
|[[:human genes:w:wdr24|WDR24]]|0.416|
|[[:human genes:e:eif4e|EIF4E]]|0.416|
|[[:human genes:v:vezt|VEZT]]|0.416|
|[[:human genes:p:pars2|PARS2]]|0.414|
|[[:human genes:a:atp5c1|ATP5C1]]|0.413|
|[[:human genes:s:sars2|SARS2]]|0.413|
|[[:human genes:v:vrk1|VRK1]]|0.413|
|[[:human genes:v:vmp1|VMP1]]|0.411|
|[[:human genes:m:mrps6|MRPS6]]|0.411|
|[[:human genes:p:pgs1|PGS1]]|0.411|
|[[:human genes:m:mbtps2|MBTPS2]]|0.411|
|[[:human genes:a:atp2a2|ATP2A2]]|0.41|
|[[:human genes:p:pelo|PELO]]|0.409|
|[[:human genes:r:rabif|RABIF]]|0.409|
|[[:human genes:p:polr3h|POLR3H]]|0.409|
|[[:human genes:y:yars2|YARS2]]|0.409|
|[[:human genes:p:pdpk1|PDPK1]]|0.409|
|[[:human genes:m:meaf6|MEAF6]]|0.408|
|[[:human genes:p:pgm3|PGM3]]|0.408|
|[[:human genes:l:lsm10|LSM10]]|0.408|
|[[:human genes:t:tgs1|TGS1]]|0.408|
|[[:human genes:d:dad1|DAD1]]|0.408|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.407|
|[[:human genes:f:fam210a|FAM210A]]|0.407|
|[[:human genes:z:zfp91|ZFP91]]|0.406|
|[[:human genes:f:fastkd5|FASTKD5]]|0.406|
|[[:human genes:v:vars2|VARS2]]|0.406|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.406|
|[[:human genes:r:rpusd4|RPUSD4]]|0.405|
|[[:human genes:e:eno1|ENO1]]|0.405|
|[[:human genes:b:bcs1l|BCS1L]]|0.403|
|[[:human genes:m:mrpl47|MRPL47]]|0.403|
|[[:human genes:c:cept1|CEPT1]]|0.403|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.403|
|[[:human genes:h:hars2|HARS2]]|0.402|
|[[:human genes:s:suv420h1|SUV420H1]]|0.402|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.402|
|[[:human genes:c:cep57|CEP57]]|0.402|
|[[:human genes:n:nsd1|NSD1]]|0.402|
|[[:human genes:u:uba5|UBA5]]|0.401|
|[[:human genes:k:kdsr|KDSR]]|0.401|
|[[:human genes:f:faf2|FAF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/26|
|bone|1/26|
|breast|3/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|1/18|
|liver|0/19|
|lung|5/72|
|lymphocyte|6/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|1/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAZ Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>