======= TBCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBCD
  * **<color #00a2e8>Official Name</color>**: tubulin folding cofactor D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6904|6904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTW9|Q9BTW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604649|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFCD C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-chaperonin tubulin folding pathway|
|tubulin complex assembly|
|negative regulation of microtubule polymerization|
|adherens junction assembly|
|bicellular tight junction assembly|
|negative regulation of microtubule polymerization or depolymerization|
|tight junction assembly|
|beta-tubulin binding|
|tight junction organization|
|apical junction assembly|
|regulation of microtubule polymerization|
|lateral plasma membrane|
|negative regulation of cell-substrate adhesion|
|adherens junction|
|negative regulation of protein polymerization|
|regulation of microtubule polymerization or depolymerization|
|adherens junction organization|
|chaperone binding|
|cell-cell junction assembly|
|bicellular tight junction|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|cell-cell junction organization|
|negative regulation of cytoskeleton organization|
|cell junction assembly|
|regulation of microtubule cytoskeleton organization|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|protein folding|
|negative regulation of cell adhesion|
|GTPase activator activity|
|microtubule|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|positive regulation of GTPase activity|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|centrosome|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|microtubule-based process|
|regulation of cell adhesion|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cellular component biogenesis|
|neuron differentiation|
|cytoskeleton organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-3.03|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.64|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.55|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.43|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.32|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.26|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.2|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.17|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.15|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.13|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.08|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.04|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.01|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.99|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.92|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.86|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.85|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.82|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.82|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.81|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.81|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.78|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.77|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.74|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.73|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.572|
|[[:human genes:a:arl2|ARL2]]|0.513|
|[[:human genes:n:nsmce1|NSMCE1]]|0.484|
|[[:human genes:n:nars|NARS]]|0.477|
|[[:human genes:m:mars|MARS]]|0.473|
|[[:human genes:e:eprs|EPRS]]|0.464|
|[[:human genes:t:tbca|TBCA]]|0.461|
|[[:human genes:h:hspd1|HSPD1]]|0.459|
|[[:human genes:s:seh1l|SEH1L]]|0.439|
|[[:human genes:s:sssca1|SSSCA1]]|0.438|
|[[:human genes:t:tti2|TTI2]]|0.438|
|[[:human genes:r:rnmt|RNMT]]|0.437|
|[[:human genes:g:gmppb|GMPPB]]|0.437|
|[[:human genes:y:yars|YARS]]|0.435|
|[[:human genes:p:pmpcb|PMPCB]]|0.434|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.429|
|[[:human genes:e:eif4e|EIF4E]]|0.428|
|[[:human genes:c:csnk2b|CSNK2B]]|0.426|
|[[:human genes:g:gtf3a|GTF3A]]|0.425|
|[[:human genes:t:telo2|TELO2]]|0.417|
|[[:human genes:p:polr3a|POLR3A]]|0.417|
|[[:human genes:s:spcs2|SPCS2]]|0.415|
|[[:human genes:p:pam16|PAM16]]|0.409|
|[[:human genes:r:rptor|RPTOR]]|0.404|
|[[:human genes:u:uxt|UXT]]|0.403|
|[[:human genes:h:haus8|HAUS8]]|0.402|
|[[:human genes:a:anapc13|ANAPC13]]|0.401|
|[[:human genes:a:adsl|ADSL]]|0.401|
|[[:human genes:r:rpe|RPE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 449/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|18/28|
|bone|19/26|
|breast|18/33|
|central nervous system|39/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|7/21|
|liver|11/20|
|lung|42/75|
|lymphocyte|12/16|
|ovary|13/26|
|pancreas|10/24|
|peripheral nervous system|11/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|18/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 932
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBCD Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>