======= TBRG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBRG4
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta regulator 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9238|9238]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969Z0|Q969Z0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBRG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBRG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053). {ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAST 1|
|FAST 2|
|RAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial mRNA processing|
|regulation of mitochondrial mRNA stability|
|mitochondrial RNA processing|
|mitochondrial RNA metabolic process|
|mitochondrial gene expression|
|cell cycle arrest|
|cellular respiration|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|energy derivation by oxidation of organic compounds|
|protein kinase activity|
|regulation of mRNA metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|negative regulation of cell cycle|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|positive regulation of cell population proliferation|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of catabolic process|
|cell cycle process|
|regulation of cell cycle|
|mitochondrion|
|phosphorylation|
|cell cycle|
|RNA binding|
|regulation of cell population proliferation|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.72|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.6|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.82|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.86|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.89|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.96|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.99|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.99|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.01|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.17|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.45|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.47|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.64|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.69|
|[[:results:exp224|CB-839 10μM R05 exp224]]|3.01|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fastkd5|FASTKD5]]|0.468|
|[[:human genes:s:selrc1|SELRC1]]|0.445|
|[[:human genes:m:mrps34|MRPS34]]|0.434|
|[[:human genes:m:mrps24|MRPS24]]|0.428|
|[[:human genes:l:lrpprc|LRPPRC]]|0.423|
|[[:human genes:u:uqcc1|UQCC1]]|0.412|
|[[:human genes:m:mrps25|MRPS25]]|0.41|
|[[:human genes:s:sco2|SCO2]]|0.41|
|[[:human genes:r:rpusd4|RPUSD4]]|0.409|
|[[:human genes:m:mrpl21|MRPL21]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3117
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBRG4 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>