======= TBX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBX3
  * **<color #00a2e8>Official Name</color>**: T-box transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6926|6926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15119|O15119]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. {ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:22002537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|T-box|
|TBX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|follicle-stimulating hormone secretion|
|atrioventricular bundle cell differentiation|
|sinoatrial node cell development|
|His-Purkinje system cell differentiation|
|sinoatrial node cell differentiation|
|sinoatrial node development|
|luteinizing hormone secretion|
|mammary placode formation|
|specification of animal organ position|
|cardiac pacemaker cell development|
|bundle of His development|
|gonadotropin secretion|
|His-Purkinje system development|
|cardiac pacemaker cell differentiation|
|cardiac muscle cell fate commitment|
|mammary gland formation|
|cardiac cell fate commitment|
|endocrine hormone secretion|
|ectodermal placode morphogenesis|
|ectodermal placode formation|
|cardiac conduction system development|
|ectodermal placode development|
|anterior/posterior axis specification, embryo|
|muscle cell fate commitment|
|tripartite regional subdivision|
|female genitalia development|
|blastoderm segmentation|
|branching involved in mammary gland duct morphogenesis|
|male genitalia development|
|negative regulation of myoblast differentiation|
|embryonic hindlimb morphogenesis|
|mammary gland duct morphogenesis|
|cellular senescence|
|embryonic forelimb morphogenesis|
|hindlimb morphogenesis|
|embryonic axis specification|
|positive regulation of stem cell proliferation|
|negative regulation of epithelial cell differentiation|
|forelimb morphogenesis|
|ventricular septum morphogenesis|
|mammary gland morphogenesis|
|genitalia development|
|endocrine process|
|anterior/posterior axis specification|
|RNA polymerase II activating transcription factor binding|
|regulation of myoblast differentiation|
|ventricular cardiac muscle tissue development|
|mammary gland epithelium development|
|heart looping|
|cardiac muscle cell development|
|embryonic digit morphogenesis|
|RNA polymerase II transcription factor binding|
|embryonic pattern specification|
|cell aging|
|regulation of stem cell proliferation|
|cardiac cell development|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|mesoderm morphogenesis|
|ventricular septum development|
|hormone secretion|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|embryonic heart tube development|
|hormone transport|
|axis specification|
|cardiac muscle cell differentiation|
|cell fate specification|
|roof of mouth development|
|segmentation|
|gland morphogenesis|
|female sex differentiation|
|limbic system development|
|cardiac septum development|
|cardiocyte differentiation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|mammary gland development|
|cardiac ventricle development|
|branching morphogenesis of an epithelial tube|
|stem cell population maintenance|
|striated muscle cell development|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|muscle cell development|
|limb morphogenesis|
|appendage morphogenesis|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|cardiac muscle tissue development|
|morphogenesis of a branching structure|
|signal release|
|cardiac chamber development|
|limb development|
|appendage development|
|striated muscle cell differentiation|
|anterior/posterior pattern specification|
|muscle cell differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|heart morphogenesis|
|sex differentiation|
|aging|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle tissue development|
|epithelial tube morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regionalization|
|in utero embryonic development|
|positive regulation of cell cycle|
|forebrain development|
|gland development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|regulation of hormone levels|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell differentiation|
|brain development|
|head development|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|epithelium development|
|cell-cell signaling|
|secretion|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.02|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBX3 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>