======= TCF21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCF21
  * **<color #00a2e8>Official Name</color>**: transcription factor 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6943|6943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43680|O43680]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCF21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCF21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bronchiole development|
|metanephric glomerulus morphogenesis|
|branchiomeric skeletal muscle development|
|metanephric glomerulus vasculature morphogenesis|
|metanephric glomerular capillary formation|
|glomerulus vasculature morphogenesis|
|glomerular capillary formation|
|metanephric mesenchymal cell differentiation|
|metanephric glomerulus vasculature development|
|lung vasculature development|
|renal system vasculature morphogenesis|
|kidney vasculature morphogenesis|
|mesenchymal cell differentiation involved in kidney development|
|mesenchymal cell differentiation involved in renal system development|
|glomerulus morphogenesis|
|diaphragm development|
|metanephric glomerulus development|
|metanephric mesenchyme development|
|negative regulation of androgen receptor signaling pathway|
|cell differentiation involved in metanephros development|
|embryonic digestive tract morphogenesis|
|kidney mesenchyme development|
|glomerulus vasculature development|
|renal system vasculature development|
|kidney vasculature development|
|Sertoli cell differentiation|
|sex determination|
|bHLH transcription factor binding|
|regulation of androgen receptor signaling pathway|
|metanephric nephron development|
|spleen development|
|embryonic digestive tract development|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|cell differentiation involved in kidney development|
|lung alveolus development|
|lung morphogenesis|
|androgen receptor binding|
|branching involved in ureteric bud morphogenesis|
|digestive tract morphogenesis|
|E-box binding|
|glomerulus development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|regulation of intracellular steroid hormone receptor signaling pathway|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|roof of mouth development|
|mesonephros development|
|nephron epithelium development|
|histone deacetylase binding|
|skeletal muscle tissue development|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|skeletal muscle organ development|
|male gonad development|
|development of primary male sexual characteristics|
|digestive system development|
|mesenchymal cell differentiation|
|male sex differentiation|
|protein dimerization activity|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|respiratory system development|
|gonad development|
|development of primary sexual characteristics|
|mesenchyme development|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sex differentiation|
|kidney development|
|striated muscle tissue development|
|renal system development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|angiogenesis|
|urogenital system development|
|blood vessel morphogenesis|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCF21 Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>