======= TCHP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCHP
  * **<color #00a2e8>Official Name</color>**: trichoplein keratin filament binding
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84260|84260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT92|Q9BT92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCHP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCHP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612654|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|apical cortex|
|negative regulation of cilium assembly|
|negative regulation of plasma membrane bounded cell projection assembly|
|desmosome|
|negative regulation of organelle assembly|
|regulation of cilium assembly|
|keratin filament|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|negative regulation of growth|
|negative regulation of organelle organization|
|regulation of cell growth|
|centrosome|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|apoptotic process|
|regulation of cellular component biogenesis|
|programmed cell death|
|cell death|
|cell projection organization|
|mitochondrion|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.14|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.95|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.94|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.93|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.86|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.76|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.74|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.71|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.87|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.98|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.99|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.99|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.06|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.11|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCHP Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>