======= TCP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCP1
  * **<color #00a2e8>Official Name</color>**: t-complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6950|6950]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17987|P17987]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translocation of peptides or proteins into host cell cytoplasm|
|translocation of peptides or proteins into host|
|translocation of peptides or proteins into other organism involved in symbiotic interaction|
|RNA localization to nucleus|
|scaRNA localization to Cajal body|
|RNA localization to Cajal body|
|zona pellucida receptor complex|
|translocation of molecules into host|
|translocation of molecules into other organism involved in symbiotic interaction|
|regulation of protein localization to Cajal body|
|positive regulation of protein localization to Cajal body|
|tubulin complex assembly|
|regulation of macrophage apoptotic process|
|positive regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to telomere|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of establishment of protein localization to chromosome|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|pericentriolar material|
|nuclear heterochromatin|
|regulation of myeloid cell apoptotic process|
|positive regulation of telomere maintenance via telomerase|
|binding of sperm to zona pellucida|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|toxin transport|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|sperm-egg recognition|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|multi-organism localization|
|cell-cell recognition|
|multi-organism transport|
|cell body|
|positive regulation of protein localization to nucleus|
|regulation of telomere maintenance|
|regulation of leukocyte apoptotic process|
|acrosomal vesicle|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|unfolded protein binding|
|single fertilization|
|interaction with host|
|fertilization|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|RNA localization|
|protein folding|
|cell recognition|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|centrosome|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of establishment of protein localization|
|symbiotic process|
|interspecies interaction between organisms|
|sexual reproduction|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|regulation of transferase activity|
|Golgi apparatus|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|response to cytokine|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|ATP binding|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell death|
|positive regulation of molecular function|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.74|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.1|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.598|
|[[:human genes:v:vbp1|VBP1]]|0.5|
|[[:human genes:s:sssca1|SSSCA1]]|0.451|
|[[:human genes:p:pdcd5|PDCD5]]|0.425|
|[[:human genes:p:pfdn1|PFDN1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 731/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.88 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCP1 Expression in NALM6 Cells: 8.88'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>