======= TEN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TEN1
  * **<color #00a2e8>Official Name</color>**: TEN1 subunit of CST complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100134934|100134934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WV5|Q86WV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TEN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TEN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). {ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:25483097}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CST complex|
|telomerase inhibitor activity|
|negative regulation of telomerase activity|
|telomere capping|
|negative regulation of telomere maintenance via telomerase|
|negative regulation of telomere maintenance via telomere lengthening|
|telomeric DNA binding|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|negative regulation of transferase activity|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|negative regulation of cellular component organization|
|DNA metabolic process|
|negative regulation of catalytic activity|
|regulation of transferase activity|
|chromosome organization|
|negative regulation of molecular function|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.39|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.35|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.33|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-2.18|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.16|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.16|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.1|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.98|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.97|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.95|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.92|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.92|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.89|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.88|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.87|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.85|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.83|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.81|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.81|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.81|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.8|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.79|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.78|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.77|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.76|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctc1|CTC1]]|0.64|
|[[:human genes:t:thg1l|THG1L]]|0.626|
|[[:human genes:g:gemin8|GEMIN8]]|0.607|
|[[:human genes:g:gemin6|GEMIN6]]|0.598|
|[[:human genes:r:rpia|RPIA]]|0.597|
|[[:human genes:t:trmt61a|TRMT61A]]|0.594|
|[[:human genes:p:ppcs|PPCS]]|0.574|
|[[:human genes:r:rpp21|RPP21]]|0.565|
|[[:human genes:h:hars|HARS]]|0.564|
|[[:human genes:s:srp14|SRP14]]|0.559|
|[[:human genes:v:vezt|VEZT]]|0.543|
|[[:human genes:l:lsm10|LSM10]]|0.542|
|[[:human genes:o:obfc1|OBFC1]]|0.539|
|[[:human genes:d:dhrsx|DHRSX]]|0.538|
|[[:human genes:d:dnlz|DNLZ]]|0.537|
|[[:human genes:a:alg1|ALG1]]|0.531|
|[[:human genes:g:gemin7|GEMIN7]]|0.53|
|[[:human genes:u:uhrf1|UHRF1]]|0.53|
|[[:human genes:a:atxn10|ATXN10]]|0.528|
|[[:human genes:p:pmm2|PMM2]]|0.528|
|[[:human genes:a:alg13|ALG13]]|0.525|
|[[:human genes:m:msto1|MSTO1]]|0.522|
|[[:human genes:p:ppcdc|PPCDC]]|0.52|
|[[:human genes:c:c15orf41|C15orf41]]|0.519|
|[[:human genes:r:rft1|RFT1]]|0.518|
|[[:human genes:p:pmvk|PMVK]]|0.517|
|[[:human genes:r:rabggtb|RABGGTB]]|0.515|
|[[:human genes:u:uap1|UAP1]]|0.514|
|[[:human genes:t:triap1|TRIAP1]]|0.514|
|[[:human genes:r:rtcb|RTCB]]|0.512|
|[[:human genes:d:dohh|DOHH]]|0.51|
|[[:human genes:c:cep57|CEP57]]|0.509|
|[[:human genes:c:chchd4|CHCHD4]]|0.507|
|[[:human genes:r:rptor|RPTOR]]|0.505|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.503|
|[[:human genes:t:tamm41|TAMM41]]|0.5|
|[[:human genes:r:rad50|RAD50]]|0.497|
|[[:human genes:p:pgm3|PGM3]]|0.493|
|[[:human genes:t:tbcb|TBCB]]|0.488|
|[[:human genes:a:adsl|ADSL]]|0.487|
|[[:human genes:d:dr1|DR1]]|0.485|
|[[:human genes:g:gmppb|GMPPB]]|0.485|
|[[:human genes:d:ddx55|DDX55]]|0.483|
|[[:human genes:u:utp23|UTP23]]|0.481|
|[[:human genes:n:nae1|NAE1]]|0.479|
|[[:human genes:d:dpagt1|DPAGT1]]|0.476|
|[[:human genes:t:tsen54|TSEN54]]|0.474|
|[[:human genes:d:ddx39a|DDX39A]]|0.472|
|[[:human genes:e:eif3f|EIF3F]]|0.471|
|[[:human genes:p:ptar1|PTAR1]]|0.47|
|[[:human genes:m:mrps34|MRPS34]]|0.469|
|[[:human genes:n:nbn|NBN]]|0.469|
|[[:human genes:t:tmem242|TMEM242]]|0.468|
|[[:human genes:z:znhit1|ZNHIT1]]|0.468|
|[[:human genes:e:eftud1|EFTUD1]]|0.468|
|[[:human genes:d:dhps|DHPS]]|0.468|
|[[:human genes:p:pelo|PELO]]|0.464|
|[[:human genes:d:dolk|DOLK]]|0.463|
|[[:human genes:e:exoc4|EXOC4]]|0.462|
|[[:human genes:s:slc25a19|SLC25A19]]|0.459|
|[[:human genes:l:lsm11|LSM11]]|0.458|
|[[:human genes:a:atic|ATIC]]|0.458|
|[[:human genes:d:ddx20|DDX20]]|0.456|
|[[:human genes:x:xrcc2|XRCC2]]|0.456|
|[[:human genes:z:zrsr2|ZRSR2]]|0.455|
|[[:human genes:p:ppp4c|PPP4C]]|0.453|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.452|
|[[:human genes:p:ppa2|PPA2]]|0.45|
|[[:human genes:e:eef1e1|EEF1E1]]|0.45|
|[[:human genes:r:rbbp4|RBBP4]]|0.449|
|[[:human genes:p:pgs1|PGS1]]|0.448|
|[[:human genes:f:fen1|FEN1]]|0.448|
|[[:human genes:s:slc25a26|SLC25A26]]|0.447|
|[[:human genes:r:rfk|RFK]]|0.447|
|[[:human genes:r:rnmt|RNMT]]|0.446|
|[[:human genes:t:tprkb|TPRKB]]|0.445|
|[[:human genes:f:fnta|FNTA]]|0.443|
|[[:human genes:t:tpk1|TPK1]]|0.442|
|[[:human genes:p:ppp6c|PPP6C]]|0.442|
|[[:human genes:e:elp2|ELP2]]|0.441|
|[[:human genes:t:trmt6|TRMT6]]|0.44|
|[[:human genes:s:ssb|SSB]]|0.44|
|[[:human genes:m:mcm9|MCM9]]|0.439|
|[[:human genes:u:urm1|URM1]]|0.438|
|[[:human genes:t:tgs1|TGS1]]|0.436|
|[[:human genes:f:fh|FH]]|0.436|
|[[:human genes:b:bcs1l|BCS1L]]|0.434|
|[[:human genes:o:osgep|OSGEP]]|0.432|
|[[:human genes:h:haus8|HAUS8]]|0.432|
|[[:human genes:r:rpe|RPE]]|0.432|
|[[:human genes:g:gfpt1|GFPT1]]|0.428|
|[[:human genes:p:ppa1|PPA1]]|0.428|
|[[:human genes:s:srd5a3|SRD5A3]]|0.426|
|[[:human genes:t:txnl4b|TXNL4B]]|0.426|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.426|
|[[:human genes:e:elac2|ELAC2]]|0.425|
|[[:human genes:t:taf1a|TAF1A]]|0.424|
|[[:human genes:p:pdap1|PDAP1]]|0.424|
|[[:human genes:k:kdsr|KDSR]]|0.423|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.422|
|[[:human genes:c:c1d|C1D]]|0.421|
|[[:human genes:t:tubd1|TUBD1]]|0.42|
|[[:human genes:g:gnb1l|GNB1L]]|0.42|
|[[:human genes:d:dpf2|DPF2]]|0.419|
|[[:human genes:y:yars2|YARS2]]|0.419|
|[[:human genes:u:uxt|UXT]]|0.419|
|[[:human genes:s:sars2|SARS2]]|0.418|
|[[:human genes:t:ttc4|TTC4]]|0.418|
|[[:human genes:z:zcrb1|ZCRB1]]|0.416|
|[[:human genes:p:pggt1b|PGGT1B]]|0.416|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.414|
|[[:human genes:w:wdr1|WDR1]]|0.413|
|[[:human genes:n:nhp2|NHP2]]|0.413|
|[[:human genes:e:ercc2|ERCC2]]|0.412|
|[[:human genes:w:wdr24|WDR24]]|0.41|
|[[:human genes:g:ggps1|GGPS1]]|0.409|
|[[:human genes:e:eno1|ENO1]]|0.409|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.408|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.408|
|[[:human genes:n:nsmce1|NSMCE1]]|0.408|
|[[:human genes:p:pdcd5|PDCD5]]|0.408|
|[[:human genes:t:tars2|TARS2]]|0.407|
|[[:human genes:m:mocs3|MOCS3]]|0.407|
|[[:human genes:s:selrc1|SELRC1]]|0.407|
|[[:human genes:m:med16|MED16]]|0.407|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.406|
|[[:human genes:s:snapc5|SNAPC5]]|0.405|
|[[:human genes:t:tma16|TMA16]]|0.405|
|[[:human genes:y:yars|YARS]]|0.403|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.403|
|[[:human genes:w:wrb|WRB]]|0.402|
|[[:human genes:c:c17orf89|C17orf89]]|0.401|
|[[:human genes:g:gemin4|GEMIN4]]|0.401|
|[[:human genes:a:atm|ATM]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 129/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|10/28|
|bone|1/26|
|breast|7/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|3/20|
|lung|9/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TEN1 Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>