======= TERF2IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TERF2IP
  * **<color #00a2e8>Official Name</color>**: TERF2 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54386|54386]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYB0|Q9NYB0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TERF2IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TERF2IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-bind 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of DNA recombination at telomere|
|negative regulation of DNA recombination at telomere|
|protection from non-homologous end joining at telomere|
|shelterin complex|
|Mre11 complex|
|nuclear telomere cap complex|
|G-rich strand telomeric DNA binding|
|telomere maintenance in response to DNA damage|
|protein localization to chromosome, telomeric region|
|telomere capping|
|telomere maintenance via telomerase|
|telomeric DNA binding|
|nuclear chromosome|
|telomere maintenance via telomere lengthening|
|RNA-dependent DNA biosynthetic process|
|negative regulation of telomere maintenance|
|positive regulation of protein acetylation|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|phosphatase binding|
|chromosome, telomeric region|
|protein localization to chromosome|
|regulation of protein acetylation|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of double-strand break repair|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|regulation of DNA recombination|
|positive regulation of peptidyl-serine phosphorylation|
|DNA biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|nuclear chromosome, telomeric region|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|negative regulation of chromosome organization|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of NF-kappaB transcription factor activity|
|nuclear envelope|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of response to DNA damage stimulus|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of DNA-binding transcription factor activity|
|nuclear body|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of phosphorylation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.91|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.76|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.72|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.87|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TERF2IP Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>