======= TESC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TESC
  * **<color #00a2e8>Official Name</color>**: tescalcin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54997|54997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BS2|Q96BS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TESC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TESC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611585|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of sodium:proton antiporter activity|
|phosphatase inhibitor activity|
|regulation of sodium:proton antiporter activity|
|positive regulation of megakaryocyte differentiation|
|positive regulation of granulocyte differentiation|
|regulation of granulocyte differentiation|
|positive regulation of sodium ion transmembrane transporter activity|
|positive regulation of sodium ion transmembrane transport|
|regulation of proton transport|
|protein kinase inhibitor activity|
|positive regulation of sodium ion transport|
|regulation of cell adhesion mediated by integrin|
|regulation of sodium ion transmembrane transporter activity|
|regulation of megakaryocyte differentiation|
|positive regulation of myeloid leukocyte differentiation|
|regulation of sodium ion transmembrane transport|
|cellular response to retinoic acid|
|regulation of sodium ion transport|
|positive regulation of myeloid cell differentiation|
|ruffle|
|ruffle membrane|
|positive regulation of ion transmembrane transporter activity|
|response to retinoic acid|
|positive regulation of transporter activity|
|regulation of myeloid leukocyte differentiation|
|positive regulation of cation transmembrane transport|
|positive regulation of leukocyte differentiation|
|positive regulation of ion transmembrane transport|
|protein stabilization|
|lamellipodium|
|protein localization to plasma membrane|
|positive regulation of hemopoiesis|
|positive regulation of transmembrane transport|
|cellular response to acid chemical|
|magnesium ion binding|
|negative regulation of protein kinase activity|
|protein maturation|
|regulation of myeloid cell differentiation|
|protein localization to cell periphery|
|negative regulation of kinase activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|regulation of protein stability|
|regulation of cation transmembrane transport|
|response to acid chemical|
|regulation of metal ion transport|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|cellular response to lipid|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of ion transport|
|calcium ion binding|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.8|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.94|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.03|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12734
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TESC Expression in NALM6 Cells: -1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>