======= TF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TF
  * **<color #00a2e8>Official Name</color>**: transferrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7018|7018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02787|P02787]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transferrin|
|Phosphonate-bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trivalent inorganic cation transport|
|ferric iron transmembrane transporter activity|
|iron chaperone activity|
|regulation of iron ion transport|
|transferrin receptor binding|
|HFE-transferrin receptor complex|
|extrinsic component of external side of plasma membrane|
|cellular response to iron ion|
|ferric iron binding|
|basal part of cell|
|iron ion transmembrane transport|
|ferrous iron binding|
|response to iron ion|
|basal plasma membrane|
|transferrin transport|
|positive regulation of receptor-mediated endocytosis|
|clathrin-coated vesicle membrane|
|clathrin-coated pit|
|endocytic vesicle|
|cellular iron ion homeostasis|
|iron ion transport|
|retina homeostasis|
|iron ion homeostasis|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|cellular transition metal ion homeostasis|
|secretory granule lumen|
|recycling endosome|
|transition metal ion transport|
|late endosome|
|platelet degranulation|
|transition metal ion homeostasis|
|vesicle|
|blood microparticle|
|tissue homeostasis|
|cellular response to metal ion|
|regulation of endocytosis|
|endosome membrane|
|cellular response to inorganic substance|
|cytoplasmic vesicle|
|early endosome|
|regulation of protein stability|
|endoplasmic reticulum lumen|
|apical plasma membrane|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|post-translational protein modification|
|response to metal ion|
|regulation of metal ion transport|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|exocytosis|
|cation transport|
|membrane organization|
|cellular homeostasis|
|ion transmembrane transport|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|chemical homeostasis|
|secretion|
|positive regulation of cellular component organization|
|transmembrane transport|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.09|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.74|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15495
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TF Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>