======= TFAP2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFAP2B
  * **<color #00a2e8>Official Name</color>**: transcription factor AP-2 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7021|7021]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92481|Q92481]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFAP2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFAP2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601601|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TF AP-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular urea homeostasis|
|cellular creatinine homeostasis|
|cellular ammonia homeostasis|
|creatinine homeostasis|
|ammonia homeostasis|
|urea homeostasis|
|ductus arteriosus closure|
|phosphate ion homeostasis|
|magnesium ion homeostasis|
|trivalent inorganic anion homeostasis|
|divalent inorganic anion homeostasis|
|collecting duct development|
|distal tubule development|
|positive regulation of urine volume|
|sympathetic nervous system development|
|retina layer formation|
|regulation of urine volume|
|enhancer sequence-specific DNA binding|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|monovalent inorganic anion homeostasis|
|aorta morphogenesis|
|potassium ion homeostasis|
|metanephric nephron development|
|sodium ion homeostasis|
|renal water homeostasis|
|hindlimb morphogenesis|
|forelimb morphogenesis|
|autonomic nervous system development|
|retina morphogenesis in camera-type eye|
|aorta development|
|positive regulation of neuron apoptotic process|
|anion homeostasis|
|neural retina development|
|artery morphogenesis|
|multicellular organismal water homeostasis|
|water homeostasis|
|nephron tubule development|
|renal tubule development|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|metanephros development|
|artery development|
|regulation of BMP signaling pathway|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of neuron death|
|nephron epithelium development|
|fat cell differentiation|
|renal system process|
|camera-type eye morphogenesis|
|glucose metabolic process|
|nephron development|
|kidney epithelium development|
|monovalent inorganic cation homeostasis|
|retina development in camera-type eye|
|negative regulation of neuron apoptotic process|
|eye morphogenesis|
|limb morphogenesis|
|appendage morphogenesis|
|hexose metabolic process|
|protein dimerization activity|
|regulation of insulin secretion|
|limb development|
|appendage development|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of peptide hormone secretion|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|transcription corepressor activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|sensory organ morphogenesis|
|regulation of hormone secretion|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|transcription coactivator activity|
|renal system development|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|urogenital system development|
|multicellular organismal homeostasis|
|negative regulation of proteolysis|
|eye development|
|visual system development|
|sensory system development|
|skin development|
|chromatin binding|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|regulation of peptidase activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|carbohydrate metabolic process|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|regulation of hormone levels|
|sensory organ development|
|metal ion homeostasis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|animal organ morphogenesis|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8851
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFAP2B Expression in NALM6 Cells: -2.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>