======= TGFB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFB3
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7043|7043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10600|P10600]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in embryogenesis and cell differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of hypoxia|
|detection of oxygen|
|regulation of tight junction disassembly|
|uterine wall breakdown|
|positive regulation of tight junction disassembly|
|type III transforming growth factor beta receptor binding|
|frontal suture morphogenesis|
|ossification involved in bone remodeling|
|negative regulation of macrophage cytokine production|
|embryonic neurocranium morphogenesis|
|type II transforming growth factor beta receptor binding|
|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|cranial suture morphogenesis|
|type I transforming growth factor beta receptor binding|
|regulation of cardiac epithelial to mesenchymal transition|
|positive regulation of SMAD protein signal transduction|
|response to laminar fluid shear stress|
|regulation of macrophage cytokine production|
|negative regulation of vascular smooth muscle cell proliferation|
|craniofacial suture morphogenesis|
|transforming growth factor beta binding|
|regulation of SMAD protein signal transduction|
|secondary palate development|
|negative regulation of cytokine production involved in immune response|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|salivary gland morphogenesis|
|positive regulation of filopodium assembly|
|salivary gland development|
|face morphogenesis|
|response to fluid shear stress|
|negative regulation of production of molecular mediator of immune response|
|regulation of collagen biosynthetic process|
|head morphogenesis|
|positive regulation of bone mineralization|
|regulation of heart morphogenesis|
|regulation of collagen metabolic process|
|lung alveolus development|
|transforming growth factor beta receptor binding|
|ovulation cycle process|
|T-tubule|
|exocrine system development|
|negative regulation of smooth muscle cell proliferation|
|regulation of filopodium assembly|
|embryonic cranial skeleton morphogenesis|
|response to progesterone|
|body morphogenesis|
|bone remodeling|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|face development|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of stress fiber assembly|
|SMAD protein signal transduction|
|regulation of pathway-restricted SMAD protein phosphorylation|
|positive regulation of actin filament bundle assembly|
|cranial skeletal system development|
|ovulation cycle|
|platelet alpha granule lumen|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|regulation of bone mineralization|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|response to estrogen|
|regulation of stress fiber assembly|
|regulation of epithelial to mesenchymal transition|
|regulation of cytokine production involved in immune response|
|positive regulation of ossification|
|positive regulation of cell division|
|regulation of actomyosin structure organization|
|roof of mouth development|
|regulation of actin filament bundle assembly|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|embryonic skeletal system morphogenesis|
|gland morphogenesis|
|tissue remodeling|
|positive regulation of plasma membrane bounded cell projection assembly|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|bone morphogenesis|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|odontogenesis|
|negative regulation of immune effector process|
|embryonic skeletal system development|
|mammary gland development|
|platelet degranulation|
|digestive tract development|
|regulation of smooth muscle cell proliferation|
|cell-cell junction organization|
|regulation of production of molecular mediator of immune response|
|digestive system development|
|negative regulation of neuron apoptotic process|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of immune response|
|activation of MAPK activity|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|growth factor activity|
|regulation of cell division|
|lung development|
|respiratory tube development|
|cytokine activity|
|female pregnancy|
|regulation of ossification|
|inner ear development|
|response to ketone|
|respiratory system development|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|multi-multicellular organism process|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|ear development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of actin filament organization|
|positive regulation of MAP kinase activity|
|ossification|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cytokine production|
|rhythmic process|
|aging|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|regulation of neuron death|
|response to steroid hormone|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|neuronal cell body|
|in utero embryonic development|
|response to oxygen levels|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of protein transport|
|embryonic organ development|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|wound healing|
|protein heterodimerization activity|
|skeletal system development|
|regulation of peptide secretion|
|cellular response to growth factor stimulus|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|detection of chemical stimulus|
|response to growth factor|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|sensory organ development|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|cell surface|
|positive regulation of organelle organization|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|detection of stimulus|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|head development|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.9|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.72|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFB3 Expression in NALM6 Cells: 1.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>