======= TGFBI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFBI
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta induced
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7045|7045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15582|Q15582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFBI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFBI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601692|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fasciclin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular matrix binding|
|cell adhesion molecule binding|
|collagen binding|
|chondrocyte differentiation|
|basement membrane|
|integrin binding|
|extracellular matrix structural constituent|
|trans-Golgi network|
|cartilage development|
|visual perception|
|sensory perception of light stimulus|
|connective tissue development|
|extracellular matrix|
|negative regulation of cell adhesion|
|angiogenesis|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood vessel morphogenesis|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|tube morphogenesis|
|regulation of cell adhesion|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|sensory perception|
|nervous system process|
|extracellular space|
|tissue development|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15511
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFBI Expression in NALM6 Cells: -1.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>