======= TGFBR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFBR2
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7048|7048]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37173|P37173]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFBR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFBR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ecTbetaR2|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of tolerance induction to self antigen|
|superior endocardial cushion morphogenesis|
|cell proliferation involved in endocardial cushion morphogenesis|
|inferior endocardial cushion morphogenesis|
|regulation of tolerance induction to self antigen|
|miRNA transport|
|regulation of B cell tolerance induction|
|bronchus morphogenesis|
|positive regulation of B cell tolerance induction|
|growth plate cartilage chondrocyte growth|
|cell proliferation involved in heart morphogenesis|
|positive regulation of NK T cell differentiation|
|growth plate cartilage chondrocyte development|
|lens fiber cell apoptotic process|
|chondrocyte hypertrophy|
|endocardial cushion fusion|
|cell adhesion involved in heart morphogenesis|
|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|positive regulation of CD4-positive, alpha-beta T cell proliferation|
|tricuspid valve morphogenesis|
|transforming growth factor beta receptor activity, type II|
|positive regulation of skeletal muscle tissue regeneration|
|regulation of NK T cell differentiation|
|tricuspid valve development|
|positive regulation of T cell tolerance induction|
|trachea formation|
|common-partner SMAD protein phosphorylation|
|lung lobe morphogenesis|
|lung lobe development|
|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|
|transmembrane receptor protein serine/threonine kinase activity|
|positive regulation of cardiac epithelial to mesenchymal transition|
|regulation of skeletal muscle tissue regeneration|
|regulation of T cell tolerance induction|
|positive regulation of tolerance induction|
|bronchus development|
|membranous septum morphogenesis|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of cardiac epithelial to mesenchymal transition|
|trachea morphogenesis|
|type I transforming growth factor beta receptor binding|
|pathway-restricted SMAD protein phosphorylation|
|negative regulation of cardiac muscle cell proliferation|
|cardiac left ventricle morphogenesis|
|transforming growth factor beta-activated receptor activity|
|regulation of tolerance induction|
|myeloid dendritic cell differentiation|
|mitogen-activated protein kinase kinase kinase binding|
|positive regulation of alpha-beta T cell proliferation|
|trachea development|
|embryonic hemopoiesis|
|myeloid dendritic cell activation|
|transforming growth factor beta binding|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|atrioventricular valve morphogenesis|
|glycosaminoglycan binding|
|secondary palate development|
|chondrocyte development involved in endochondral bone morphogenesis|
|growth plate cartilage chondrocyte differentiation|
|positive regulation of mesenchymal cell proliferation|
|response to cholesterol|
|atrioventricular valve development|
|epithelial cell apoptotic process|
|outflow tract septum morphogenesis|
|branching involved in blood vessel morphogenesis|
|response to sterol|
|regulation of alpha-beta T cell proliferation|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|negative regulation of organ growth|
|growth factor binding|
|dendritic cell differentiation|
|negative regulation of cardiac muscle tissue development|
|regulation of mesenchymal cell proliferation|
|growth plate cartilage development|
|animal organ formation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|endocardial cushion morphogenesis|
|embryo implantation|
|regulation of cardiac muscle cell proliferation|
|regulation of heart morphogenesis|
|ventricular septum morphogenesis|
|endochondral bone growth|
|mammary gland morphogenesis|
|endocardial cushion development|
|chondrocyte development|
|lung morphogenesis|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|embryonic cranial skeleton morphogenesis|
|positive regulation of alpha-beta T cell differentiation|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|mesenchyme morphogenesis|
|negative regulation of muscle tissue development|
|SMAD binding|
|heart valve morphogenesis|
|positive regulation of wound healing|
|regulation of cardiac muscle tissue growth|
|heart looping|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|heart valve development|
|regulation of alpha-beta T cell differentiation|
|positive regulation of response to wounding|
|regulation of heart growth|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|cranial skeletal system development|
|vasculogenesis|
|smoothened signaling pathway|
|ventricular septum development|
|endochondral bone morphogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|animal organ regeneration|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|caveola|
|response to estrogen|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|embryonic heart tube development|
|lens development in camera-type eye|
|regulation of cardiac muscle tissue development|
|positive regulation of animal organ morphogenesis|
|positive regulation of T cell differentiation|
|peptidyl-threonine phosphorylation|
|chondrocyte differentiation|
|regulation of epithelial to mesenchymal transition|
|positive regulation of smooth muscle cell proliferation|
|developmental cell growth|
|cell growth|
|roof of mouth development|
|peptidyl-threonine modification|
|regulation of alpha-beta T cell activation|
|regulation of organ growth|
|positive regulation of lymphocyte differentiation|
|embryonic skeletal system morphogenesis|
|positive regulation of T cell proliferation|
|positive regulation of reactive oxygen species metabolic process|
|organ growth|
|gland morphogenesis|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of developmental growth|
|cardiac septum development|
|myeloid leukocyte differentiation|
|bone morphogenesis|
|regulation of transforming growth factor beta receptor signaling pathway|
|developmental growth involved in morphogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|Notch signaling pathway|
|embryonic skeletal system development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|mammary gland development|
|positive regulation of lymphocyte proliferation|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|positive regulation of mononuclear cell proliferation|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of leukocyte proliferation|
|regulation of wound healing|
|response to glucose|
|regulation of T cell differentiation|
|positive regulation of epithelial cell migration|
|digestive system development|
|response to hexose|
|positive regulation of leukocyte differentiation|
|negative regulation of cellular response to growth factor stimulus|
|response to monosaccharide|
|cellular response to transforming growth factor beta stimulus|
|regeneration|
|regulation of T cell proliferation|
|gastrulation|
|morphogenesis of a branching epithelium|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|regulation of lymphocyte differentiation|
|morphogenesis of a branching structure|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|cartilage development|
|response to carbohydrate|
|respiratory tube development|
|peptidyl-serine phosphorylation|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|positive regulation of vasculature development|
|positive regulation of hemopoiesis|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|peptidyl-serine modification|
|bone development|
|positive regulation of T cell activation|
|receptor complex|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|response to mechanical stimulus|
|response to nutrient|
|RNA localization|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of epithelial cell migration|
|mesenchyme development|
|regulation of leukocyte proliferation|
|connective tissue development|
|membrane raft|
|response to alcohol|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor-mediated endocytosis|
|skeletal system morphogenesis|
|nucleobase-containing compound transport|
|negative regulation of growth|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of cellular response to growth factor stimulus|
|regulation of leukocyte differentiation|
|aging|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|camera-type eye development|
|regulation of T cell activation|
|angiogenesis|
|regulation of vasculature development|
|response to steroid hormone|
|activation of protein kinase activity|
|regulation of developmental growth|
|leukocyte differentiation|
|response to hypoxia|
|response to decreased oxygen levels|
|eye development|
|positive regulation of lymphocyte activation|
|visual system development|
|sensory system development|
|in utero embryonic development|
|response to oxygen levels|
|developmental growth|
|growth|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|gland development|
|positive regulation of cell activation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of hemopoiesis|
|wound healing|
|blood vessel development|
|skeletal system development|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|endocytosis|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|regulation of cell activation|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of growth|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.72|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.85|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.07|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.19|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.47|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFBR2 Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>