======= TGM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGM2
  * **<color #00a2e8>Official Name</color>**: transglutaminase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7052|7052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21980|P21980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190196|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transglut C|
|Transglut core|
|Transglut N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|
|isopeptide cross-linking|
|peptidyl-glutamine modification|
|tube lumen cavitation|
|salivary gland cavitation|
|negative regulation of endoplasmic reticulum calcium ion concentration|
|protein-glutamine gamma-glutamyltransferase activity|
|positive regulation of mitochondrial calcium ion concentration|
|branching involved in salivary gland morphogenesis|
|endoplasmic reticulum calcium ion homeostasis|
|mitochondrial calcium ion homeostasis|
|salivary gland morphogenesis|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|salivary gland development|
|blood vessel remodeling|
|intrinsic component of plasma membrane|
|apoptotic cell clearance|
|exocrine system development|
|peptide cross-linking|
|positive regulation of smooth muscle cell proliferation|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|gland morphogenesis|
|tissue remodeling|
|regulation of smooth muscle cell proliferation|
|positive regulation of inflammatory response|
|tube formation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|protein domain specific binding|
|positive regulation of cytosolic calcium ion concentration|
|peptidyl-lysine modification|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|regulation of inflammatory response|
|protein homooligomerization|
|collagen-containing extracellular matrix|
|GTP binding|
|positive regulation of cell adhesion|
|gland development|
|focal adhesion|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of cell adhesion|
|positive regulation of cell death|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|ion homeostasis|
|tube development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|mitochondrion|
|G protein-coupled receptor signaling pathway|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.77|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.76|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.74|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.74|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15731
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGM2 Expression in NALM6 Cells: 2.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>