======= THBD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THBD
  * **<color #00a2e8>Official Name</color>**: thrombomodulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7056|7056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07204|P07204]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THBD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THBD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tme5 EGF like|
|cEGF|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fibrinolysis|
|regulation of fibrinolysis|
|apicolateral plasma membrane|
|negative regulation of platelet activation|
|positive regulation of hemostasis|
|vacuolar membrane|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|response to X-ray|
|regulation of platelet activation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|response to cAMP|
|response to organophosphorus|
|transmembrane signaling receptor activity|
|regulation of wound healing|
|response to ionizing radiation|
|response to purine-containing compound|
|regulation of response to wounding|
|female pregnancy|
|negative regulation of cell activation|
|signaling receptor activity|
|multi-multicellular organism process|
|blood coagulation|
|coagulation|
|hemostasis|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|negative regulation of response to external stimulus|
|leukocyte migration|
|response to radiation|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|positive regulation of response to external stimulus|
|cell surface|
|regulation of cell activation|
|response to bacterium|
|calcium ion binding|
|response to lipid|
|response to organic cyclic compound|
|cell migration|
|multi-organism reproductive process|
|response to organonitrogen compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THBD Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>