======= THBS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THBS1
  * **<color #00a2e8>Official Name</color>**: thrombospondin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7057|7057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07996|P07996]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THBS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THBS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). {ECO:0000250, ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:15014436}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|TSP 1|
|EGF 3|
|EGF CA|
|TSP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen V binding|
|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|negative regulation of nitric oxide mediated signal transduction|
|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|negative regulation of long-chain fatty acid import across plasma membrane|
|negative regulation of long-chain fatty acid import into cell|
|regulation of long-chain fatty acid import across plasma membrane|
|negative regulation of dendritic cell antigen processing and presentation|
|negative regulation of endothelial cell chemotaxis|
|regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|fibrinogen binding|
|regulation of long-chain fatty acid import into cell|
|negative regulation of plasminogen activation|
|negative regulation of cGMP-mediated signaling|
|positive regulation of transforming growth factor beta1 production|
|negative regulation of fatty acid transport|
|fibrinogen complex|
|negative regulation of antigen processing and presentation|
|regulation of nitric oxide mediated signal transduction|
|negative regulation of fibrinolysis|
|chronic inflammatory response|
|regulation of dendritic cell antigen processing and presentation|
|regulation of transforming growth factor beta1 production|
|positive regulation of fibroblast migration|
|engulfment of apoptotic cell|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of plasminogen activation|
|regulation of cGMP-mediated signaling|
|platelet alpha granule|
|behavioral response to pain|
|regulation of fibrinolysis|
|proteoglycan binding|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of anion transmembrane transport|
|negative regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of macrophage chemotaxis|
|negative regulation of interleukin-12 production|
|low-density lipoprotein particle binding|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|negative regulation of focal adhesion assembly|
|positive regulation of transforming growth factor beta production|
|positive regulation of endothelial cell apoptotic process|
|positive regulation of macrophage migration|
|negative regulation of organic acid transport|
|positive regulation of tumor necrosis factor biosynthetic process|
|regulation of antigen processing and presentation|
|response to magnesium ion|
|negative regulation of adherens junction organization|
|regulation of endothelial cell chemotaxis|
|transforming growth factor beta binding|
|negative regulation of cell junction assembly|
|fibroblast growth factor binding|
|positive regulation of macrophage activation|
|negative regulation of sprouting angiogenesis|
|laminin binding|
|negative regulation of lipid transport|
|positive regulation of blood coagulation|
|regulation of macrophage chemotaxis|
|positive regulation of hemostasis|
|regulation of anion transmembrane transport|
|positive regulation of coagulation|
|fibronectin binding|
|regulation of fatty acid transport|
|negative regulation of anion transport|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|response to pain|
|regulation of fibroblast migration|
|regulation of tumor necrosis factor biosynthetic process|
|positive regulation of epithelial cell apoptotic process|
|negative regulation of blood vessel endothelial cell migration|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of transforming growth factor beta production|
|negative regulation of endothelial cell proliferation|
|regulation of macrophage migration|
|negative regulation of cell-matrix adhesion|
|response to testosterone|
|regulation of cell migration involved in sprouting angiogenesis|
|apoptotic cell clearance|
|negative regulation of lipid localization|
|regulation of granulocyte chemotaxis|
|sarcoplasmic reticulum|
|response to progesterone|
|regulation of mononuclear cell migration|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of endothelial cell migration|
|regulation of endothelial cell apoptotic process|
|regulation of macrophage activation|
|regulation of interleukin-12 production|
|positive regulation of wound healing|
|regulation of megakaryocyte differentiation|
|positive regulation of blood vessel endothelial cell migration|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of chemotaxis|
|sprouting angiogenesis|
|regulation of organic acid transport|
|phosphatidylserine binding|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|peptide cross-linking|
|negative regulation of cell-substrate adhesion|
|positive regulation of response to wounding|
|negative regulation of epithelial cell migration|
|regulation of protein processing|
|platelet alpha granule lumen|
|positive regulation of cytokine biosynthetic process|
|regulation of adherens junction organization|
|multicellular organismal response to stress|
|regulation of protein maturation|
|regulation of sprouting angiogenesis|
|cellular response to heat|
|regulation of blood coagulation|
|regulation of epithelial cell apoptotic process|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of tumor necrosis factor production|
|secretory granule|
|positive regulation of leukocyte chemotaxis|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of cell junction assembly|
|regulation of blood vessel endothelial cell migration|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of ion transmembrane transport|
|regulation of anion transport|
|positive regulation of endothelial cell migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cytokine biosynthetic process|
|negative regulation of blood vessel morphogenesis|
|regulation of lipid transport|
|response to heat|
|regulation of leukocyte chemotaxis|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cell-matrix adhesion|
|negative regulation of vasculature development|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane transport|
|negative regulation of epithelial cell proliferation|
|positive regulation of translation|
|positive regulation of leukocyte migration|
|platelet degranulation|
|regulation of endothelial cell proliferation|
|phagocytosis, engulfment|
|integrin binding|
|extracellular matrix structural constituent|
|regulation of smooth muscle cell proliferation|
|positive regulation of chemotaxis|
|regulation of wound healing|
|response to glucose|
|regulation of lipid localization|
|plasma membrane invagination|
|positive regulation of epithelial cell migration|
|response to hexose|
|membrane invagination|
|cell cycle arrest|
|negative regulation of ion transport|
|negative regulation of cellular response to growth factor stimulus|
|response to monosaccharide|
|regulation of tumor necrosis factor production|
|response to calcium ion|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|response to unfolded protein|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|heparin binding|
|response to carbohydrate|
|positive regulation of apoptotic signaling pathway|
|response to temperature stimulus|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|response to topologically incorrect protein|
|response to ketone|
|regulation of leukocyte migration|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|regulation of chemotaxis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|extracellular matrix|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|response to endoplasmic reticulum stress|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|regulation of angiogenesis|
|endoplasmic reticulum lumen|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to steroid hormone|
|activation of protein kinase activity|
|phagocytosis|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|response to hypoxia|
|regulation of translation|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|response to metal ion|
|response to oxygen levels|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|blood vessel development|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|endocytosis|
|regulation of transmembrane transport|
|behavior|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|calcium ion binding|
|regulation of proteolysis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|response to lipid|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|secretion by cell|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|cell cycle|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.34|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.91|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THBS1 Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>