======= THOC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THOC1
  * **<color #00a2e8>Official Name</color>**: THO complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9984|9984]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FV9|Q96FV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THOC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THOC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|efThoc1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of isotype switching to IgA isotypes|
|negative regulation of isotype switching|
|negative regulation of DNA damage checkpoint|
|THO complex|
|negative regulation of cell cycle checkpoint|
|regulation of isotype switching to IgA isotypes|
|THO complex part of transcription export complex|
|viral mRNA export from host cell nucleus|
|translocation of molecules into other organism involved in symbiotic interaction|
|translocation of molecules into host|
|negative regulation of B cell mediated immunity|
|negative regulation of immunoglobulin mediated immune response|
|negative regulation of immunoglobulin production|
|transcription export complex|
|regulation of DNA damage checkpoint|
|negative regulation of B cell activation|
|positive regulation of DNA-templated transcription, elongation|
|regulation of cell cycle checkpoint|
|replication fork processing|
|regulation of isotype switching|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte mediated immunity|
|DNA-dependent DNA replication maintenance of fidelity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|negative regulation of DNA recombination|
|negative regulation of leukocyte mediated immunity|
|regulation of DNA-templated transcription, elongation|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|intercellular bridge|
|regulation of immunoglobulin production|
|multi-organism transport|
|multi-organism localization|
|negative regulation of response to DNA damage stimulus|
|mRNA 3-end processing|
|regulation of DNA recombination|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear matrix|
|nuclear chromosome, telomeric region|
|negative regulation of immune effector process|
|DNA-dependent DNA replication|
|negative regulation of DNA metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|protein export from nucleus|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|mRNA transport|
|interaction with host|
|nuclear export|
|regulation of adaptive immune response|
|negative regulation of leukocyte activation|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|negative regulation of cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|DNA replication|
|RNA localization|
|regulation of response to DNA damage stimulus|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|RNA splicing|
|nuclear speck|
|negative regulation of immune system process|
|regulation of immune effector process|
|mRNA processing|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|mRNA metabolic process|
|regulation of cellular response to stress|
|DNA metabolic process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|apoptotic process|
|negative regulation of developmental process|
|intracellular protein transport|
|programmed cell death|
|cell death|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.7|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.74|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.76|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.435|
|[[:human genes:n:nup43|NUP43]]|0.433|
|[[:human genes:u:ubap1|UBAP1]]|0.421|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.412|
|[[:human genes:s:supt5h|SUPT5H]]|0.412|
|[[:human genes:p:psmd3|PSMD3]]|0.41|
|[[:human genes:o:or10g3|OR10G3]]|0.41|
|[[:human genes:r:rpsa|RPSA]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 517/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|21/28|
|bone|18/26|
|breast|21/33|
|central nervous system|40/56|
|cervix|2/4|
|colorectal|15/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|13/21|
|liver|18/20|
|lung|51/75|
|lymphocyte|11/16|
|ovary|20/26|
|pancreas|16/24|
|peripheral nervous system|8/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|17/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THOC1 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>