======= THOC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THOC3
  * **<color #00a2e8>Official Name</color>**: THO complex 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84321|84321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96J01|Q96J01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THOC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THOC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606929|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|eIF2A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|THO complex part of transcription export complex|
|viral mRNA export from host cell nucleus|
|translocation of molecules into host|
|translocation of molecules into other organism involved in symbiotic interaction|
|transcription export complex|
|multi-organism localization|
|multi-organism transport|
|mRNA 3-end processing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear chromosome, telomeric region|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|interaction with host|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|intracellular protein transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.74|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gmppb|GMPPB]]|0.522|
|[[:human genes:t:telo2|TELO2]]|0.505|
|[[:human genes:a:adsl|ADSL]]|0.48|
|[[:human genes:y:yars|YARS]]|0.47|
|[[:human genes:n:nars|NARS]]|0.464|
|[[:human genes:c:cct7|CCT7]]|0.461|
|[[:human genes:e:eny2|ENY2]]|0.458|
|[[:human genes:r:rnmt|RNMT]]|0.455|
|[[:human genes:d:dpagt1|DPAGT1]]|0.452|
|[[:human genes:g:gfpt1|GFPT1]]|0.452|
|[[:human genes:r:rptor|RPTOR]]|0.446|
|[[:human genes:w:wars|WARS]]|0.446|
|[[:human genes:e:exoc4|EXOC4]]|0.446|
|[[:human genes:e:eprs|EPRS]]|0.441|
|[[:human genes:o:oip5|OIP5]]|0.44|
|[[:human genes:h:haus8|HAUS8]]|0.435|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.43|
|[[:human genes:g:gnb1l|GNB1L]]|0.425|
|[[:human genes:h:hspd1|HSPD1]]|0.424|
|[[:human genes:m:mars|MARS]]|0.423|
|[[:human genes:e:eno1|ENO1]]|0.422|
|[[:human genes:p:pmm2|PMM2]]|0.421|
|[[:human genes:c:csnk2b|CSNK2B]]|0.42|
|[[:human genes:z:znf259|ZNF259]]|0.417|
|[[:human genes:a:alg13|ALG13]]|0.417|
|[[:human genes:r:rtcb|RTCB]]|0.416|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.416|
|[[:human genes:s:seh1l|SEH1L]]|0.415|
|[[:human genes:m:med16|MED16]]|0.414|
|[[:human genes:a:alg2|ALG2]]|0.413|
|[[:human genes:a:alg1|ALG1]]|0.412|
|[[:human genes:n:nsmce1|NSMCE1]]|0.409|
|[[:human genes:r:rpp21|RPP21]]|0.407|
|[[:human genes:z:znhit1|ZNHIT1]]|0.401|
|[[:human genes:t:thg1l|THG1L]]|0.401|
|[[:human genes:s:sugt1|SUGT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 501/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|22/28|
|bone|19/26|
|breast|17/33|
|central nervous system|33/56|
|cervix|1/4|
|colorectal|14/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|10/21|
|liver|14/20|
|lung|57/75|
|lymphocyte|13/16|
|ovary|13/26|
|pancreas|18/24|
|peripheral nervous system|9/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THOC3 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>