======= THOC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THOC5
  * **<color #00a2e8>Official Name</color>**: THO complex 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8563|8563]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13769|Q13769]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THOC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THOC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FimP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|THO complex|
|negative regulation of DNA damage checkpoint|
|THO complex part of transcription export complex|
|primitive hemopoiesis|
|negative regulation of cell cycle checkpoint|
|viral mRNA export from host cell nucleus|
|translocation of molecules into other organism involved in symbiotic interaction|
|translocation of molecules into host|
|transcription export complex|
|regulation of DNA damage checkpoint|
|mononuclear cell differentiation|
|monocyte differentiation|
|embryonic hemopoiesis|
|nuclear chromosome|
|positive regulation of DNA-templated transcription, elongation|
|regulation of cell cycle checkpoint|
|regulation of DNA-templated transcription, elongation|
|multi-organism localization|
|multi-organism transport|
|negative regulation of response to DNA damage stimulus|
|mRNA 3-end processing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|nuclear chromosome, telomeric region|
|myeloid leukocyte differentiation|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|interaction with host|
|nuclear export|
|mRNA binding|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|regulation of response to DNA damage stimulus|
|myeloid cell differentiation|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|leukocyte differentiation|
|positive regulation of cell cycle|
|RNA splicing|
|embryonic organ development|
|mRNA processing|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|mRNA metabolic process|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|embryo development|
|intracellular protein transport|
|regulation of cell cycle|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 311/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|19/28|
|bone|8/26|
|breast|20/33|
|central nervous system|22/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|6/21|
|liver|3/20|
|lung|37/75|
|lymphocyte|8/16|
|ovary|13/26|
|pancreas|12/24|
|peripheral nervous system|2/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2374
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THOC5 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>