======= THOC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THOC6
  * **<color #00a2e8>Official Name</color>**: THO complex 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79228|79228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86W42|Q86W42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THOC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THOC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615403|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|THO complex|
|THO complex part of transcription export complex|
|viral mRNA export from host cell nucleus|
|translocation of molecules into host|
|translocation of molecules into other organism involved in symbiotic interaction|
|transcription export complex|
|multi-organism localization|
|multi-organism transport|
|mRNA 3-end processing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear chromosome, telomeric region|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|interaction with host|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|central nervous system development|
|negative regulation of cell death|
|intracellular protein transport|
|programmed cell death|
|cell death|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|regulation of cell death|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.92|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.84|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.82|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.73|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.72|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.81|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.08|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mllt1|MLLT1]]|0.606|
|[[:human genes:h:hars|HARS]]|0.585|
|[[:human genes:f:fbxo11|FBXO11]]|0.575|
|[[:human genes:m:mapk14|MAPK14]]|0.551|
|[[:human genes:c:ccdc101|CCDC101]]|0.545|
|[[:human genes:p:pmm2|PMM2]]|0.535|
|[[:human genes:n:nxt1|NXT1]]|0.535|
|[[:human genes:u:ube2g1|UBE2G1]]|0.53|
|[[:human genes:m:med23|MED23]]|0.528|
|[[:human genes:e:eny2|ENY2]]|0.518|
|[[:human genes:m:meaf6|MEAF6]]|0.518|
|[[:human genes:d:dpagt1|DPAGT1]]|0.516|
|[[:human genes:m:med16|MED16]]|0.509|
|[[:human genes:a:atf7ip|ATF7IP]]|0.506|
|[[:human genes:w:wdr24|WDR24]]|0.505|
|[[:human genes:c:cbx3|CBX3]]|0.502|
|[[:human genes:u:uap1|UAP1]]|0.499|
|[[:human genes:o:otud5|OTUD5]]|0.499|
|[[:human genes:t:triap1|TRIAP1]]|0.498|
|[[:human genes:r:rptor|RPTOR]]|0.496|
|[[:human genes:a:alg1|ALG1]]|0.491|
|[[:human genes:g:gfpt1|GFPT1]]|0.491|
|[[:human genes:c:csnk2b|CSNK2B]]|0.488|
|[[:human genes:t:tceb3|TCEB3]]|0.486|
|[[:human genes:d:dnajc3|DNAJC3]]|0.485|
|[[:human genes:t:tti2|TTI2]]|0.483|
|[[:human genes:r:rnmt|RNMT]]|0.48|
|[[:human genes:u:ube3a|UBE3A]]|0.48|
|[[:human genes:h:hccs|HCCS]]|0.479|
|[[:human genes:u:ubr5|UBR5]]|0.479|
|[[:human genes:p:pelo|PELO]]|0.475|
|[[:human genes:p:pax5|PAX5]]|0.474|
|[[:human genes:g:gnb1l|GNB1L]]|0.473|
|[[:human genes:u:uhrf1|UHRF1]]|0.468|
|[[:human genes:m:med13l|MED13L]]|0.468|
|[[:human genes:a:atp5j|ATP5J]]|0.467|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.466|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.466|
|[[:human genes:u:ube2l3|UBE2L3]]|0.466|
|[[:human genes:n:nupl2|NUPL2]]|0.464|
|[[:human genes:d:dcaf5|DCAF5]]|0.463|
|[[:human genes:m:med25|MED25]]|0.461|
|[[:human genes:a:alg5|ALG5]]|0.459|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.456|
|[[:human genes:h:hhex|HHEX]]|0.454|
|[[:human genes:d:dhx29|DHX29]]|0.454|
|[[:human genes:o:oraov1|ORAOV1]]|0.45|
|[[:human genes:b:btaf1|BTAF1]]|0.449|
|[[:human genes:w:wdr59|WDR59]]|0.449|
|[[:human genes:a:aars|AARS]]|0.444|
|[[:human genes:t:thg1l|THG1L]]|0.443|
|[[:human genes:c:casp9|CASP9]]|0.443|
|[[:human genes:d:dohh|DOHH]]|0.442|
|[[:human genes:g:gmppb|GMPPB]]|0.442|
|[[:human genes:d:dad1|DAD1]]|0.441|
|[[:human genes:m:med13|MED13]]|0.44|
|[[:human genes:a:alg13|ALG13]]|0.44|
|[[:human genes:c:cycs|CYCS]]|0.44|
|[[:human genes:d:dpf2|DPF2]]|0.438|
|[[:human genes:m:max|MAX]]|0.437|
|[[:human genes:m:mtor|MTOR]]|0.437|
|[[:human genes:g:gfer|GFER]]|0.435|
|[[:human genes:t:tle4|TLE4]]|0.432|
|[[:human genes:r:rtcb|RTCB]]|0.432|
|[[:human genes:h:hspd1|HSPD1]]|0.431|
|[[:human genes:b:bap1|BAP1]]|0.43|
|[[:human genes:m:mios|MIOS]]|0.429|
|[[:human genes:c:crls1|CRLS1]]|0.427|
|[[:human genes:a:atxn10|ATXN10]]|0.427|
|[[:human genes:t:tti1|TTI1]]|0.427|
|[[:human genes:t:trmt5|TRMT5]]|0.427|
|[[:human genes:s:sec16a|SEC16A]]|0.425|
|[[:human genes:k:kctd5|KCTD5]]|0.424|
|[[:human genes:t:timm13|TIMM13]]|0.424|
|[[:human genes:d:dhps|DHPS]]|0.422|
|[[:human genes:c:cul4a|CUL4A]]|0.422|
|[[:human genes:g:glmn|GLMN]]|0.421|
|[[:human genes:t:tmem41b|TMEM41B]]|0.421|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.421|
|[[:human genes:t:tp53|TP53]]|0.42|
|[[:human genes:s:serf2|SERF2]]|0.42|
|[[:human genes:u:uba3|UBA3]]|0.42|
|[[:human genes:p:polr3h|POLR3H]]|0.418|
|[[:human genes:t:tada1|TADA1]]|0.417|
|[[:human genes:s:spop|SPOP]]|0.415|
|[[:human genes:t:telo2|TELO2]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.415|
|[[:human genes:f:fnip1|FNIP1]]|0.414|
|[[:human genes:z:znf592|ZNF592]]|0.413|
|[[:human genes:a:alg2|ALG2]]|0.411|
|[[:human genes:p:pum1|PUM1]]|0.41|
|[[:human genes:e:elac2|ELAC2]]|0.409|
|[[:human genes:n:nup50|NUP50]]|0.409|
|[[:human genes:v:vcpip1|VCPIP1]]|0.407|
|[[:human genes:r:rbm17|RBM17]]|0.407|
|[[:human genes:e:elf2|ELF2]]|0.407|
|[[:human genes:v:vmp1|VMP1]]|0.407|
|[[:human genes:o:opa1|OPA1]]|0.405|
|[[:human genes:r:romo1|ROMO1]]|0.404|
|[[:human genes:t:tbp|TBP]]|0.403|
|[[:human genes:u:ube2j1|UBE2J1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THOC6 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>