======= THRAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THRAP3
  * **<color #00a2e8>Official Name</color>**: thyroid hormone receptor associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9967|9967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2W1|Q9Y2W1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THRAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THRAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603809|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin D receptor binding|
|positive regulation of circadian rhythm|
|exon-exon junction complex|
|positive regulation of mRNA splicing, via spliceosome|
|thyroid hormone receptor binding|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|phosphoprotein binding|
|mediator complex|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|regulation of alternative mRNA splicing, via spliceosome|
|nuclear receptor transcription coactivator activity|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|transcription coregulator activity|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of mRNA splicing, via spliceosome|
|regulation of circadian rhythm|
|regulation of RNA splicing|
|regulation of mRNA processing|
|circadian rhythm|
|transcription initiation from RNA polymerase II promoter|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|DNA-templated transcription, initiation|
|mRNA catabolic process|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|rhythmic process|
|transcription coactivator activity|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|posttranscriptional regulation of gene expression|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.9|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.74|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.96|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.01|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.01|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.87|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THRAP3 Expression in NALM6 Cells: 8.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>