======= THRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THRB
  * **<color #00a2e8>Official Name</color>**: thyroid hormone receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7068|7068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10828|P10828]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561, ECO:0000269|PubMed:19926848}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of eye photoreceptor cell development|
|female courtship behavior|
|retinal cone cell apoptotic process|
|negative regulation of eye photoreceptor cell development|
|courtship behavior|
|thyroid hormone mediated signaling pathway|
|retinal cell apoptotic process|
|negative regulation of female receptivity|
|type I pneumocyte differentiation|
|thyroid hormone binding|
|negative regulation of photoreceptor cell differentiation|
|regulation of female receptivity|
|regulation of photoreceptor cell differentiation|
|female mating behavior|
|retinal cone cell development|
|retinal cone cell differentiation|
|camera-type eye photoreceptor cell differentiation|
|lung epithelial cell differentiation|
|lung cell differentiation|
|mating behavior|
|thyroid gland development|
|reproductive behavior|
|lung epithelium development|
|mating|
|negative regulation of animal organ morphogenesis|
|eye photoreceptor cell development|
|neuron apoptotic process|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|nuclear receptor activity|
|retina morphogenesis in camera-type eye|
|neuron death|
|steroid hormone receptor activity|
|neural retina development|
|photoreceptor cell differentiation|
|nuclear receptor transcription coactivator activity|
|chromatin DNA binding|
|RNA polymerase II transcription factor complex|
|transcription regulatory region sequence-specific DNA binding|
|camera-type eye morphogenesis|
|steroid hormone mediated signaling pathway|
|endocrine system development|
|retina development in camera-type eye|
|sensory perception of sound|
|eye morphogenesis|
|intracellular receptor signaling pathway|
|sensory perception of mechanical stimulus|
|lung development|
|hormone-mediated signaling pathway|
|respiratory tube development|
|transcription initiation from RNA polymerase II promoter|
|cellular response to steroid hormone stimulus|
|respiratory system development|
|signaling receptor activity|
|DNA-templated transcription, initiation|
|negative regulation of neuron differentiation|
|nuclear chromatin|
|transcription corepressor activity|
|regulation of heart contraction|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|nuclear body|
|regulation of blood circulation|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to steroid hormone|
|transcription factor binding|
|negative regulation of cell development|
|enzyme binding|
|eye development|
|visual system development|
|sensory system development|
|gland development|
|transcription by RNA polymerase II|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|sensory organ development|
|behavior|
|regulation of system process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|sensory perception|
|multi-organism reproductive process|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.82|
|[[:results:exp453|B02 10μM R08 exp453]]|1.87|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6427
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THRB Expression in NALM6 Cells: 1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>