======= TIMM44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM44
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 44
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10469|10469]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43615|O43615]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605058|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source. {ECO:0000250|UniProtKB:Q01852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim44|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into mitochondrial matrix|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|chaperone binding|
|protein import|
|mitochondrial transport|
|protein targeting|
|mitochondrial matrix|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.92|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.02|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.03|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.05|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.08|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.46|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.564|
|[[:human genes:p:pmm2|PMM2]]|0.408|
|[[:human genes:c:crls1|CRLS1]]|0.403|
|[[:human genes:r:romo1|ROMO1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 225/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|5/28|
|bone|6/26|
|breast|14/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|5/21|
|liver|9/20|
|lung|27/75|
|lymphocyte|7/16|
|ovary|14/26|
|pancreas|7/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|9/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM44 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>