======= TIMMDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMMDC1
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51300|51300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPL8|Q9NPL8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMMDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMMDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615534|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.77|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.82|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.91|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.98|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.01|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.08|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.09|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.09|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.2|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.31|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.55|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.661|
|[[:human genes:n:nubpl|NUBPL]]|0.646|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.637|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.636|
|[[:human genes:n:ndufs2|NDUFS2]]|0.631|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.621|
|[[:human genes:n:ndufc2|NDUFC2]]|0.62|
|[[:human genes:m:mto1|MTO1]]|0.619|
|[[:human genes:n:ndufs8|NDUFS8]]|0.609|
|[[:human genes:n:ndufs5|NDUFS5]]|0.609|
|[[:human genes:n:ndufb11|NDUFB11]]|0.609|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.6|
|[[:human genes:g:grsf1|GRSF1]]|0.598|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.595|
|[[:human genes:n:ndufa3|NDUFA3]]|0.594|
|[[:human genes:a:acad9|ACAD9]]|0.585|
|[[:human genes:n:ndufa2|NDUFA2]]|0.575|
|[[:human genes:n:ndufb9|NDUFB9]]|0.574|
|[[:human genes:n:ndufa11|NDUFA11]]|0.57|
|[[:human genes:c:cars2|CARS2]]|0.568|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.557|
|[[:human genes:e:eral1|ERAL1]]|0.557|
|[[:human genes:n:ndufc1|NDUFC1]]|0.543|
|[[:human genes:n:ndufb7|NDUFB7]]|0.541|
|[[:human genes:n:ndufs7|NDUFS7]]|0.534|
|[[:human genes:n:ndufs3|NDUFS3]]|0.534|
|[[:human genes:n:ndufv2|NDUFV2]]|0.533|
|[[:human genes:n:ndufa8|NDUFA8]]|0.531|
|[[:human genes:n:ndufv1|NDUFV1]]|0.53|
|[[:human genes:f:ftsj2|FTSJ2]]|0.527|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.526|
|[[:human genes:e:ecsit|ECSIT]]|0.523|
|[[:human genes:m:mrpl44|MRPL44]]|0.521|
|[[:human genes:n:ndufb4|NDUFB4]]|0.516|
|[[:human genes:f:fastkd2|FASTKD2]]|0.515|
|[[:human genes:t:tfb1m|TFB1M]]|0.514|
|[[:human genes:n:ndufb5|NDUFB5]]|0.513|
|[[:human genes:p:pet117|PET117]]|0.512|
|[[:human genes:c:c1qbp|C1QBP]]|0.511|
|[[:human genes:n:ndufb10|NDUFB10]]|0.51|
|[[:human genes:g:gfm1|GFM1]]|0.504|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.501|
|[[:human genes:r:rpusd3|RPUSD3]]|0.5|
|[[:human genes:p:pet112|PET112]]|0.499|
|[[:human genes:n:ndufa5|NDUFA5]]|0.498|
|[[:human genes:c:c12orf65|C12orf65]]|0.497|
|[[:human genes:n:ndufs1|NDUFS1]]|0.497|
|[[:human genes:f:foxred1|FOXRED1]]|0.495|
|[[:human genes:n:ndufb6|NDUFB6]]|0.494|
|[[:human genes:n:ndufb2|NDUFB2]]|0.492|
|[[:human genes:m:mtif2|MTIF2]]|0.489|
|[[:human genes:p:ptcd3|PTCD3]]|0.488|
|[[:human genes:q:qrsl1|QRSL1]]|0.486|
|[[:human genes:m:mrp63|MRP63]]|0.484|
|[[:human genes:n:ndufa10|NDUFA10]]|0.482|
|[[:human genes:g:gfm2|GFM2]]|0.48|
|[[:human genes:m:mterfd1|MTERFD1]]|0.477|
|[[:human genes:n:ndufa13|NDUFA13]]|0.476|
|[[:human genes:w:wbscr16|WBSCR16]]|0.476|
|[[:human genes:c:clpp|CLPP]]|0.474|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.473|
|[[:human genes:n:ndufa6|NDUFA6]]|0.473|
|[[:human genes:n:ndufb3|NDUFB3]]|0.471|
|[[:human genes:l:lars2|LARS2]]|0.47|
|[[:human genes:p:polg2|POLG2]]|0.468|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.468|
|[[:human genes:m:mrpl21|MRPL21]]|0.467|
|[[:human genes:m:mrpl45|MRPL45]]|0.467|
|[[:human genes:m:mettl17|METTL17]]|0.467|
|[[:human genes:m:mrps26|MRPS26]]|0.467|
|[[:human genes:p:prepl|PREPL]]|0.464|
|[[:human genes:s:slc25a51|SLC25A51]]|0.463|
|[[:human genes:n:nars2|NARS2]]|0.462|
|[[:human genes:m:mcat|MCAT]]|0.462|
|[[:human genes:c:coq2|COQ2]]|0.461|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.461|
|[[:human genes:m:mrps21|MRPS21]]|0.454|
|[[:human genes:d:ddx28|DDX28]]|0.453|
|[[:human genes:r:rmnd1|RMND1]]|0.452|
|[[:human genes:n:nfu1|NFU1]]|0.452|
|[[:human genes:a:atp5sl|ATP5SL]]|0.452|
|[[:human genes:m:mrps25|MRPS25]]|0.45|
|[[:human genes:t:tefm|TEFM]]|0.45|
|[[:human genes:w:wars2|WARS2]]|0.45|
|[[:human genes:m:mrps16|MRPS16]]|0.447|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.446|
|[[:human genes:c:c17orf89|C17orf89]]|0.445|
|[[:human genes:t:tmem261|TMEM261]]|0.445|
|[[:human genes:p:pnpt1|PNPT1]]|0.443|
|[[:human genes:y:yars2|YARS2]]|0.441|
|[[:human genes:n:ndufa9|NDUFA9]]|0.441|
|[[:human genes:s:ssbp1|SSBP1]]|0.44|
|[[:human genes:d:dars2|DARS2]]|0.439|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.439|
|[[:human genes:c:coq7|COQ7]]|0.437|
|[[:human genes:e:ears2|EARS2]]|0.435|
|[[:human genes:r:rars2|RARS2]]|0.435|
|[[:human genes:m:mtg1|MTG1]]|0.433|
|[[:human genes:r:rpusd4|RPUSD4]]|0.432|
|[[:human genes:c:coa6|COA6]]|0.431|
|[[:human genes:s:selrc1|SELRC1]]|0.43|
|[[:human genes:m:mrps23|MRPS23]]|0.429|
|[[:human genes:d:dap3|DAP3]]|0.429|
|[[:human genes:t:trub2|TRUB2]]|0.429|
|[[:human genes:m:malsu1|MALSU1]]|0.428|
|[[:human genes:c:chchd1|CHCHD1]]|0.427|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.426|
|[[:human genes:i:ict1|ICT1]]|0.426|
|[[:human genes:n:noa1|NOA1]]|0.426|
|[[:human genes:c:c10orf2|C10orf2]]|0.425|
|[[:human genes:m:mrps27|MRPS27]]|0.423|
|[[:human genes:a:atp5e|ATP5E]]|0.423|
|[[:human genes:s:slc25a3|SLC25A3]]|0.423|
|[[:human genes:m:mrpl3|MRPL3]]|0.422|
|[[:human genes:n:nsun4|NSUN4]]|0.421|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.42|
|[[:human genes:s:sfxn4|SFXN4]]|0.417|
|[[:human genes:i:iba57|IBA57]]|0.414|
|[[:human genes:m:mrps12|MRPS12]]|0.413|
|[[:human genes:v:vars2|VARS2]]|0.413|
|[[:human genes:p:prim1|PRIM1]]|0.409|
|[[:human genes:p:polg|POLG]]|0.408|
|[[:human genes:c:cox20|COX20]]|0.406|
|[[:human genes:s:slc25a52|SLC25A52]]|0.406|
|[[:human genes:n:ndufb8|NDUFB8]]|0.405|
|[[:human genes:a:atp5c1|ATP5C1]]|0.403|
|[[:human genes:c:coa3|COA3]]|0.402|
|[[:human genes:c:cox16|COX16]]|0.401|
|[[:human genes:a:aars2|AARS2]]|0.4|
|[[:human genes:b:bcs1l|BCS1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMMDC1 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>