======= TIMP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMP2
  * **<color #00a2e8>Official Name</color>**: TIMP metallopeptidase inhibitor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7077|7077]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16035|P16035]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188825|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Rap protein signal transduction|
|negative regulation of metallopeptidase activity|
|negative regulation of membrane protein ectodomain proteolysis|
|positive regulation of adenylate cyclase activity|
|regulation of metallopeptidase activity|
|peptidase inhibitor activity|
|metalloendopeptidase inhibitor activity|
|positive regulation of cyclase activity|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of lyase activity|
|regulation of adenylate cyclase activity|
|regulation of cyclase activity|
|regulation of lyase activity|
|negative regulation of Ras protein signal transduction|
|tertiary granule lumen|
|negative regulation of small GTPase mediated signal transduction|
|specific granule lumen|
|extracellular matrix disassembly|
|protease binding|
|ficolin-1-rich granule lumen|
|growth cone|
|integrin binding|
|negative regulation of protein catabolic process|
|extracellular matrix|
|regulation of Ras protein signal transduction|
|negative regulation of endopeptidase activity|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|aging|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|extracellular matrix organization|
|regulation of small GTPase mediated signal transduction|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of protein catabolic process|
|extracellular structure organization|
|cellular component disassembly|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|response to hormone|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of catabolic process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMP2 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>