======= TIMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMP3
  * **<color #00a2e8>Official Name</color>**: TIMP metallopeptidase inhibitor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7078|7078]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35625|P35625]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of TRAIL-activated apoptotic signaling pathway|
|regulation of TRAIL-activated apoptotic signaling pathway|
|negative regulation of metalloendopeptidase activity|
|negative regulation of metallopeptidase activity|
|regulation of metalloendopeptidase activity|
|negative regulation of membrane protein ectodomain proteolysis|
|regulation of metallopeptidase activity|
|platelet dense granule lumen|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|metalloendopeptidase inhibitor activity|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of ERK1 and ERK2 cascade|
|basement membrane|
|protease binding|
|platelet degranulation|
|negative regulation of protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of MAPK cascade|
|positive regulation of apoptotic signaling pathway|
|visual perception|
|sensory perception of light stimulus|
|extracellular matrix|
|negative regulation of endopeptidase activity|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cellular catabolic process|
|response to hormone|
|sensory perception|
|regulation of catabolic process|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.74|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMP3 Expression in NALM6 Cells: -3.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>