======= TINF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TINF2
  * **<color #00a2e8>Official Name</color>**: TERF1 interacting nuclear factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26277|26277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSI4|Q9BSI4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TINF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TINF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604319|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|perinucleolar chromocenter|
|negative regulation of protein ADP-ribosylation|
|telomere assembly|
|shelterin complex|
|nuclear telomere cap complex|
|regulation of protein ADP-ribosylation|
|protein localization to chromosome, telomeric region|
|telomere capping|
|negative regulation of telomere maintenance via telomerase|
|telomeric DNA binding|
|negative regulation of telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|chromosome, telomeric region|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|nuclear chromosome, telomeric region|
|nuclear matrix|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of epithelial cell proliferation|
|negative regulation of chromosome organization|
|nuclear body|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|protein localization to organelle|
|DNA metabolic process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.58|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.32|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.24|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.22|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.16|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.06|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.96|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.88|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.77|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.75|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.74|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.04|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsf|NSF]]|0.462|
|[[:human genes:r:rrp7a|RRP7A]]|0.434|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:i:ik|IK]]|0.429|
|[[:human genes:r:rrm1|RRM1]]|0.419|
|[[:human genes:n:nup160|NUP160]]|0.418|
|[[:human genes:e:eif4a3|EIF4A3]]|0.415|
|[[:human genes:e:exosc6|EXOSC6]]|0.414|
|[[:human genes:c:c14orf93|C14orf93]]|0.413|
|[[:human genes:p:psmb4|PSMB4]]|0.41|
|[[:human genes:t:tceb3c|TCEB3C]]|0.408|
|[[:human genes:r:rffl|RFFL]]|0.406|
|[[:human genes:u:utp3|UTP3]]|0.406|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.402|
|[[:human genes:c:cep192|CEP192]]|0.402|
|[[:human genes:p:prpf3|PRPF3]]|0.402|
|[[:human genes:v:vps28|VPS28]]|0.402|
|[[:human genes:s:supt5h|SUPT5H]]|0.402|
|[[:human genes:r:ranbp2|RANBP2]]|0.401|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 679/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/25|
|breast|29/33|
|central nervous system|53/56|
|cervix|3/4|
|colorectal|17/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|20/21|
|liver|18/20|
|lung|67/75|
|lymphocyte|13/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TINF2 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>