======= TIPIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIPIN
  * **<color #00a2e8>Official Name</color>**: TIMELESS interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54962|54962]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVW5|Q9BVW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIPIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIPIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610716|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Swi3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|replication fork arrest|
|replication fork protection complex|
|replication fork protection|
|intra-S DNA damage checkpoint|
|DNA replication checkpoint|
|regulation of nuclear cell cycle DNA replication|
|negative regulation of DNA-dependent DNA replication|
|negative regulation of DNA replication|
|DNA-dependent DNA replication maintenance of fidelity|
|regulation of DNA-dependent DNA replication|
|mitotic DNA damage checkpoint|
|mitotic DNA integrity checkpoint|
|regulation of DNA replication|
|DNA-dependent DNA replication|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|DNA replication|
|nuclear chromatin|
|cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|response to light stimulus|
|response to radiation|
|cell division|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|positive regulation of cell population proliferation|
|cell cycle process|
|response to abiotic stimulus|
|regulation of cell cycle|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.75|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.73|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.76|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:twistnb|TWISTNB]]|0.424|
|[[:human genes:d:dtl|DTL]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 91/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|6/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|3/21|
|liver|4/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIPIN Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>